藤田医科大学医学部生化学講座

２０２４年

Kotomura N, Shimono Y, Ishihara S. CYP19A1 expression is controlled by mRNA stability of the upstream transcription factor AP-2γ in placental JEG3 cells.Endocrinology. 2024, in press. doi: 10.1210/endocr/bqae055. PMID: 38717933.

２０２３年

Khaledian B, Thibes L, Shimono Y. Adipocyte regulation of cancer stem cells. Cancer Science. 2023;114(11):4134-4144. doi: 10.1111/cas.15940.PMID: 37622414.

Toriuchi K, Kihara T, Aoki H, Kakita H, Takeshita S, Ueda H, Inoue Y, Hayashi H, Shimono Y, Yamada Y, Aoyama M. Monocyte-Derived miRNA-1914-5p Attenuates IL-1β-Induced Monocyte Adhesion and Transmigration. Int J Mol Sci. 2023;24(3):2829. doi:10.3390/ijms24032829. PMID: 36769149.

２０２２年

Hisamori S, Mukohyama J, Koul S, Hayashi T, Rothenberg ME, Maeda M, Isobe T, Valencia Salazar LE, Qian X, Johnston DM, Qian D, Lao K, Asai N, Kakeji Y, Gennarino VA, Sahoo D, Dalerba P, Shimono Y. Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells. J Gastroenterology. 2022;57(6):407-422. doi: 10.1007/s00535-022-01865-9. PMID: 35244768.

Nouchi Y, Munetsuna E, Yamada H, Yamazaki M, Ando Y, Mizuno G, Fujii R, Kageyama I, Wakasugi T, Sakakibara T, Teshigawara A, Ishikawa H, Shimono Y, Suzuki K, Hashimoto S, Ohashi K. Effects of High-Fructose Corn Syrup Intake on Glucocorticoid Metabolism in Rats During Childhood, Adolescence and Adulthood. Exp Clin Endocrinol Diabetes. 2022;130(12):814-820. doi:10.1055/a-1936-3310.

Kageyama I, Yamada H, Munetsuna E, Yamazaki M, Ando Y, Mizuno G, Fujii R, Nouchi Y, Wakasugi T, Sakakibara T, Teshigawara A, Ishikawa H, Shimono Y, Suzuki K, Hashimoto S, Ohashi K. Differential effects of excess high-fructose corn syrup on the DNA methylation of hippocampal neurotrophic factor in childhood and adolescence. PLoS One. 2022;17(6):e0270144. doi:10.1371/journal.pone.0270144. PMID: 35714129.

２０２１年

Mizuno M, Khaledian B, Maeda M, Hayashi T, Mizuno S, Munetsuna E, Watanabe T, Kono S, Okada S, Suzuki M, Takao S, Minami H, Asai N, Sugiyama F, Takahashi S, Shimono Y. Adipsin-Dependent Secretion of Hepatocyte Growth Factor Regulates the Adipocyte-Cancer Stem Cell Interaction. Cancers . 2021;13(16):e4238. doi: 10.3390/cancers13164238.

Munetsuna E, Yamada H, Yamazaki M, Ando Y, Mizuno G, Hattori Y, Kageyama I, Teshigawara A, Nouchi Y, Ishikawa H, Fujii R, Ohta Y, Suzuki K, Shimono Y, Ohashi K, Hashimoto S. Maternal fructose intake predisposes rat offspring to metabolic disorders via abnormal hepatic programming. FASEB J. 2021;35(12):e22030. doi: 10.1096/fj.202101276R.

Kotomura N, Harada N, Shimono Y, Ishihara S. Transcriptional regulation of CYP19 by cohesin-mediated chromosome tethering in human granulosa cells. Biochem Biophys Rep. 2021;27:e101086. doi: 10.1016/j.bbrep.2021.101086.

Mizuno G, Munetsuna E, Yamada H, Yamazaki M, Ando Y, Hattori Y, Kageyama I, Teshigawara A, Nouchi Y, Fujii R, Ishikawa H, Suzuki K, Hashimoto S, Ohashi K, Shimono Y. Maternal fructose consumption downregulates hippocampal catalase expression via DNA methylation in rat offspring. Nutr Res. 2021:40-48. doi: 10.1016/j.nutres.2021.06.002.

Ishihara S, Sasagawa Y, Kameda T, Yamashita H, Umeda M, Kotomura N, Abe M, Shimono Y, Nikaido I. Local states of chromatin compaction at transcription start sites control transcription levels. Nucleic Acids Res. 2021;49(14):8007-8023. doi: 10.1093/nar/gkab587.

２０２０年

Yanagi H, Watanabe T, Nishimura T, Hayashi T, Kono S, Tsuchida H, Hirata M, Kijima Y, Takao S, Okada S, Suzuki M, Imaizumi K, Kawada K, Minami H, Gotoh N, Shimono Y. Upregulation of S100A10 in metastasized breast cancer stem cells. Cancer Science. 2020;111(12):4359-4370. doi: 10.1111/cas.14659.

Nishio E, Hayashi T, Akaza M, Hisatomi Y, Hikichi M, Fujii T, Utsumi T, Harada N, Shimono Y. Upregulation of CIP2A in estrogen depletion-resistant breast cancer cells treated with low-dose everolimus. FEBS Open Bio . 2020;10:2072-2080. doi:10.1002/2211-5463.12956.

Shibuya N, Kakeji Y, Shimono Y. miR-93 targets WASF3 and functions as a metastasis suppressor in breast cancer. Cancer Science. 2020;111:2093-2103. doi: 10.1111/cas.14423.

Yamazaki M, Munetsuna E, Yamada H, Ando Y, Mizuno G, Fujii R, Nouchi Y, Kageyama I, Teshigawara A, Ishikawa H, Suzuki K, Shimono Y, Hashimoto S, Ohashi K. Maternal fructose consumption down-regulates Lxra expression via miR-206-mediated regulation. Journal of Nutritional Biochemistry. 2020;82:e108386. doi: 10.1016/j.jnutbio.2020.108386.

２０１９年

Nishiuchi A, Hisamori S, Sakaguchi M, Fukuyama K, Hoshino N, Itatani Y, Honma S, Maekawa H, Nishigori T, Tsunoda S, Obama K, Miyoshi H, Shimono Y, Taketo MM, Sakai Y. MicroRNA-9-5p-CDX2 Axis: A Useful Prognostic Biomarker for Patients with Stage II/III Colorectal Cancer. Cancers. 2019;11(12):e1891. doi: 10.3390/cancers11121891.

Mukohyama J, Isobe T, Hu Q, Hayashi T, Watanabe T, Maeda M, Yanagi H, Qian X, Yamashita K, Minami H, Mimori K, Sahoo D, Kakeji Y, Suzuki A, Dalerba P, Shimono Y. miR-221 targets QKI to enhance the tumorigenic capacity of human colorectal cancer stem cells. Cancer Research. 2019;79:5151-5158. doi:10.1158/0008-5472.CAN-18-3544

Nishio E, Hayashi T, Nakatani M, Aida N, Suda R, Wakatsuki T, Fujii T, Honda S, Harada N, Shimono Y. Lack of association of ovariectomy-induced obesity with overeating and the reduction of physical activities.Biochemistry and Biophysics Reports. 2019;20:e100671. doi:10.1016/j.bbrep.2019.100671

Honma S, Hisamori S, Nishiuchi A, Itatani Y, Obama K, Shimono Y, Sakai Y. F-Box/WD Repeat Domain-Containing 7 Induces Chemotherapy Resistance in Colorectal Cancer Stem Cells. Cancers. 2019;11(5). pii: E635. doi: 10.3390/cancers11050635.

Yamada H, Munetsuna E, Yamazaki M, Mizuno G, Sadamoto N, Ando Y, Fujii R, Shiogama K, Ishikawa H, Suzuki K, Shimono Y, Ohashi K, Hashimoto S. Maternal fructose-induced oxidative stress occurs via Tfam and Ucp5 epigenetic regulation in offspring hippocampi. FASEB J. 2019;33(10):11431-11442. doi: 10.1096/fj.201901072R.

»先代の生化学講座（原田名誉教授）の業績はこちらをご参照ください。

藤田医科大学赴任前の業績

２０１８年

２０１７年

Tominaga K, Shimamura T, Kimura N, Murayama T, Matsubara D, Kanauchi H, Niida A, Shimizu S, Nishioka K, Tsuji EI, Yano M, Sugano S, Shimono Y, Ishii H, Saya H, Mori M, Akashi K, Tada KI, Ogawa T, Tojo A, Miyano S, Gotoh N*. Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells. Oncogene, 2017; 36: 1276-1286. doi: 10.1038/onc.2016.293.

Kondo H, Shimono Y*, Mukohyama J, Tanaka Y, Shibuya N, Minami H, Kakeji Y, Suzuki A. Discordance of MCM7 mRNA and its intronic microRNA levels under hypoxia. Anticancer Research, 37: 3885-3890, 2017.

Kunimasa K, Nagano T, Shimono Y, Dokuni R, Kiriu T, Tokunaga S, Tamura D, Yamamoto M, Tachihara M, Kobayashi K, Satouchi M, Nishimura Y*. Glucose metabolism targeting therapy and withaferin A are effective for EGFR-TKI induced drug tolerant persisters. Cancer Science, 2017, 108: 1368-1377. doi:10.1111/cas.13266.

２０１６年

Mukohyama J, Iwakiri D, Zen Y, Mukohara T, Minami H, Kakeji Y, Shimono Y*. Evaluation of the risk of lymphomagenesis in xenografts by the PCR-based detection of EBV BamHI W region in patient cancer specimens. Oncotarget, 2016; 7: 50150-50160. doi: 10.18632/oncotarget.10322.

Mukohyama J, Shimono Y*, Yamashita K, Sumi Y, Mukohara T, Minami H, Kakeji Y. Effect of Xenotransplantation Site on MicroRNA Expression of Human Colon Cancer Stem Cells. Anticancer Research, 2016; 36: 3679-86.

Ijuin T, Takeuchi Y, Shimono Y, Fukumoto M, Tokuda E, Takenawa T. Regulation of CD44 expression and focal adhesion by Golgi phosphatidylinositol 4-phosphate in breast cancer. Cancer Science, 2016; 107: 981-90. doi: 10.1111/cas.12968.

Kitayama M, Mizutani K, Maruoka M, Mandai K, Sakakibara S, Ueda Y, Komori T, Shimono Y, Takai Y. A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development. Journal of Biological Chemistry, 2016; 291:5817-5831. doi: 10.1074/jbc.M115.685917.

Sakaguchi M, Hisamori S, Oshima N, Sato F, Shimono Y, Sakai Y. miR-137 Regulates the Tumorigenicity of Colon Cancer Stem Cells through the Inhibition of DCLK1. Molecular Cancer Research, 2016; 14: 354-62. doi: 10.1158/1541-7786.MCR-15-0380.

Mukohyama J, Shimono Y, Minami H, Kakeji Y, Suzuki A. Roles of microRNAs and RNA-Binding Proteins in the Regulation of Colorectal Cancer Stem Cells. Cancers. 2017;9. pii: E143. doi: 10.3390/cancers9100143.

Shimono Y*, Mukohyama J, Isobe T, Johnston DM, Dalerba P, Suzuki A. Organoid culture of human cancer stem cells, In the series Methods in Molecular Biology (Kursad Turksen, ed.), 1-9, Springer, 2016.

Shimono Y*, Mukohyama J, Nakamura S, Minami H. MicroRNA regulation of human breast cancer stem cells. Journal of Clinical Medicine, 2016; 5: e2. doi:10.3390/jcm5010002.

２０１５年

Nobutani K, Shimono Y, Mizutani K, Ueda Y, Suzuki T, Kitayama M, Minami A, Momose K, Miyawaki K, Akashi K, Azuma T, Takai Y. Downregulation of CXCR4 in metastasized breast cancer cells and implication in their dormancy. PLoSOne, 2015; 10: e0130032. doi: 10.1371/journal.pone.0130032.

Imamura Y, Mukohara T, Shimono Y, Funakoshi Y, Chayahara N, Toyoda M, Kiyota N, Takao S, Kono S, Nakatsura T, Minami H. Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer. Oncology Reports, 2015; 33: 1837-1843. doi: 10.3892/or.2015.3767.

２０１４年

Isobe T, Hisamori S, Hogan DJ, Zabala M, Hendrickson DG, Dalerba P, Cai S, Scheeren F, Kuo AH, Sikandar SS, Lam JS, Qian D, Dirbas FM, Somlo G, Lao K, Brown PO, Clarke MF, Shimono Y*. miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway. eLife, 2014; 3: e01977. doi: 10.7554/eLife.01977.

Suzuki T, Mizutani K, Minami A, Nobutani K, Kurita S, Nagino M, Shimono Y*, Takai Y*. (*Corresponding author). Suppression of the TGF-β1-induced protein expression of SNAI1 and N-cadherin by miR-199a. Genes to Cells, 2014; 19: 667-675. doi:10.1111/gtc.12166.

Nobutani K, Shimono Y, Yoshida M, Mizutani K, Minami A, Kono S, Mukohara T, Yamasaki T, Itoh T, Takao S, Minami H, Azuma T, Takai Y. Absence of primary cilia in the cell cycle-arrested human breast cancer cells. Genes to Cells, 2014; 19: 141-152.doi: 10.1111/gtc.12122.

Ekyalongo RC, Mukohara T, Funakoshi Y, Tomioka H, Kataoka Y, Shimono Y, Chayahara N, Toyoda M, Kiyota N, Minami H. TYRO3 as a potential therapeutic target in breast cancer. Anticancer Research, 2014; 34: 3337-3345.

２０１３年以前

Liu H, Patel MR, Prescher JA, Patsialou A, Qian D, Lin J, Wen S, Chang YF, Bachmann MH, Shimono Y, Dalerba P, Adorno M, Lobo N, Bueno J, Dirbas FM, Goswami S, Somlo G, Condeelis J, Contag CH, Gambhir SS, Clarke MF*. Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proceedings of the National Academy of Sciences U.S.A. 2010; 107: 18115-18120. doi: 10.1073/pnas.1006732107.

Dalerba P, Kalisky T, Sahoo D, Rajendran PS, Rothenberg ME, Leyrat AA, Sim S, Okamoto J, Johnston DM, Qian D, Zabala M, Bueno J, Neff NF, Wang J, Shelton AA, Visser B, Hisamori S, Shimono Y, van de Wetering M, Clevers H, Clarke MF, Quake SR*. Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nature Biotechnology, 2011; 29: 1120-1127. doi: 10.1038/nbt.2038.

Shimono Y, Zabala M, Cho RW, Lobo N, Dalerba P, Qian D, Diehn M, Liu H, Panula SP, Chiao E, Dirbas FM, Somlo G, Reijo Pera RA, Lao K, Clarke MF*. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell, 2009; 138: 592-603. doi: 10.1016/j.cell.2009.07.011.

Lobo NA, Shimono Y, Qian D, Clarke MF*. The biology of cancer stem cells. Annual Review of Cell and Developmental Biology, 2007; 23: 675-699.

Shimono Y, Murakami H, Hasegawa Y, Takahashi M*. RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions. Journal of Biological Chemistry, 2000; 275: 39411-39419. doi: 10.1074/jbc.M006585200