Division of Brain Thera Informatics

Projects

We have established a new research field called “BrainTheraInformatics” for the integration of information about the brain to discover novel clues for developing therapies. The Theranostics Center at Fujita Health University, featuring Positron Emission Tomography (PET), opened in May 2024. “Theranostics” is a portmanteau of “Therapy” and “Diagnostics”, referring to the integration of diagnosis and treatment. While cancer is an important focus, disease-modifying therapies for neurodegenerative disorders are a new area of research. We analyze multimodal information on neurodegenerative diseases, including clinical symptoms, MRI and PET images, and biomarkers from blood and cerebrospinal fluid, to identify “seeds” for the development of new methods of prevention and therapy. With extensive collaboration, our goal is to initiate disease-modifying therapies for neurodegenerative disorders during preclinical or early stages.

Members

Kazuya Kawabata

Kazuya Kawabata Senior Assistant Professor

My research focuses on Parkinson’s disease and other neurodegenerative disorders with the goal of clarifying the brain networks associated with higher cognitive functions and developing advanced MRI diagnostic methods. We also use PET scanning to enable a better understanding of the pathophysiology of neurodegenerative diseases. Our ongoing research aims to contribute to the invention of new diagnostic methods and therapies that will benefit patients and society.

Main publications

  1. Kawabata K, Bagarinao E, Seppi K, Poewe W. Longitudinal brain changes in Parkinson's disease with severe olfactory deficit. Parkinsonism Relat Disord. 2024 May;122:106072. doi: 10.1016/j.parkreldis.2024.106072. Epub 2024 Feb 27. PubMed PMID: 38430690. 
  2. Kawabata K, Krismer F, Heim B, Hussl A, Mueller C, Scherfler C, Gizewski ER, Seppi K, Poewe W. A Blinded Evaluation of Brain Morphometry for Differential Diagnosis of Atypical Parkinsonism.Mov Disord Clin Pract. 2024 Apr;11(4):381-390. doi: 10.1002/mdc3.13987. Epub 2024 Feb 5. PubMed PMID: 38314609; PubMed Central PMCID: PMC10982602. 
  3. Kawabata K, Djamshidian A, Bagarinao E, Weintraub D, Seppi K, Poewe W. Cognitive dysfunction in de novo Parkinson disease: Remitting vs. progressive cognitive impairment. Parkinsonism Relat Disord. 2024 Mar;120:105984. doi: 10.1016/j.parkreldis.2023.105984. Epub 2023 Dec 28. PubMed PMID: 38198926. 
  4. Kawabata K, Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Functional connector hubs in the cerebellum. Neuroimage. 2022 Aug 15;257:119263. doi: 10.1016/j.neuroimage.2022.119263. Epub 2022 Apr 29. PubMed PMID: 35500805. 
  5. Kawabata K, Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G. Bridging large-scale cortical networks: Integrative and function-specific hubs in the thalamus. iScience. 2021 Oct 22;24(10):103106. doi: 10.1016/j.isci.2021.103106. eCollection 2021 Oct 22. PubMed PMID: 34622159; PubMed Central PMCID: PMC8479782. 

Information

Division of Brain Thera Informatics(Neurology, School of Medicine)

【Address】
Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan
【Contact】
E-mail:sinkeinaika(at)yahoo.co.jp
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