Division of Neurochemistry
Projects
Preemptive medicine is a novel model of personalized medicine in which the factor of a disease is predicted at an earlier stage and regulated by therapeutic interventions. To develop preemptive medicine for neuropsychiatric diseases, our department aims at discovering the molecular targets for neuropsychiatric diseases, such as stress-induced depression and tau lesion-induced Alzheimer's disease, using animal models and clinical research in order to develop diagnostic and therapeutic agents.
Members
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Dr. Akihiro Mouri Professor of Department of Regulatory Science, Interdepartmental Collaboration Unit, Faculties of Medical Technology and Radiological technology, Fujita Health University
Our goal is to develop novel therapeutic agents, phytochemicals, and diagnostic biomarkers. This will be achieved by analyzing pathological and pathogenic mechanisms of psychiatric disorders in mouse models that we develop based on epidemiological and genetic findings in patients.
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Dr. Kazuo Kunisawa Senior Assistant Professor of Department of Regulatory Science, Interdepartmental Collaboration Unit, Faculties of Medical Technology and Radiological technology, Fujita Health University
To elucidate the pathogenesis of neuropsychiatric disorders, we are analyzing 1) peripheral-central interactions through the composition of the intestinal microflora and function of peripheral immune cells, and 2) glial-neural interactions through glial cell-specific genetic interventions.
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Prof. Kuniaki Saito Director of Faculty of Medical Sciences and Professor of Department of Advanced Diagnostic System Development, Units on Research Promotion, Faculty of Medical Sciences, Fujita Health University
Objective diagnosis and assessment of psychiatric disorders are difficult because they are based on interviews and questionnaires. Our goal is to establish new biomarkers for psychiatric disorders from blood and other sources that can be used to assess the onset and severity of symptoms, and the efficacy of medications.
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Prof. Toshitaka Nabeshima Professor of Laboratory of Health and Medical Science Innovation, Fujita Health University, Graduate School of Health Sciences
The pathogenesis and etiology of neuropsychiatric disorders are complicated and diverse. We aim to overcome neuropsychiatric disorders by integrating clinical research analyzing the biomarkers of diseases with basic research using animal models and cell culture.
Main publications
- Kubota H, Kunisawa K, Wulaer B, Hasegawa M, Kurahashi H, Sakata T, Tezuka H, Kugita M, Nagao S, Nagai T, Furuyashiki T, Narumiya S, Saito K, Nabeshima T, Mouri A. High salt induces cognitive impairment via the interaction of the angiotensin II-AT1 and prostaglandin E2-EP1 systems. Br J Pharmacol. 2023 Sep;180(18):2393-2411.
- Kosuge A, Kunisawa K, Arai S, Sugawara Y, Shinohara K, Iida T, Wulaer B, Kawai T, Fujigaki H, Yamamoto Y, Saito K, Nabeshima T, Mouri A. Heat-sterilized Bifidobacterium breve prevents depression-like behavior and interleukin-1β expression in mice exposed to chronic social defeat stress. Brain Behav Immun. 2021 Aug;96:200-211.
- Nakayama T, Okimura K, Shen J, Guh YJ, Tamai TK, Shimada A, Minou S, Okushi Y, Shimmura T, Furukawa Y, Kadofusa N, Sato A, Nishimura T, Tanaka M, Nakayama K, Shiina N, Yamamoto N, Loudon AS, Nishiwaki-Ohkawa T, Shinomiya A, Nabeshima T, Nakane Y, Yoshimura T. Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior. Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9594-9603.
- Teshigawara T, Mouri A, Kubo H, Nakamura Y, Shiino T, Okada T, Morikawa M, Nabeshima T, Ozaki N, Yamamoto Y, Saito K. Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms. J Affect Disord. 2019 Aug 1;255:168-176.
- Mouri A, Sasaki A, Watanabe K, Sogawa C, Kitayama S, Mamiya T, Miyamoto Y, Yamada K, Noda Y, Nabeshima T. MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation. J Neurosci. 2012 Mar 28;32(13):4562-80.
Information
Division of Neurochemistry（Regulatory Science, Medical Technology and Radiological Technology）
Advanced diagnostic system research lab,Fujita Health University Graduate School of Health Sciences
Japanese Drug Organization of Appropriate Use and Research(J-DO）
【Address】
#102, 10th building, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan
【Contact】
E-mail：mouri(at)fujita-hu.ac.jp ／ Tel：+81-562-93-9647
※ Please replace “(at)” with “@”.