医療科学部　臨床教育連携ユニット
分子イメージング学分野

ニュース&トピックス

• 2024年7月

• 2024年6月

• 2024年5月

• 2024年4月

• 2024年2月

• 2023年11月25–26日

• 2023年11月3-4日

• 2023年7月23日

• 2023年6月26日

• 2023年4月

分野紹介

分子イメージングは、体内で起こっていることを分子や細胞レベルで詳細に描写する画像診断手法の一種です。X線、コンピュータ断層撮影(CT)、超音波などの他の画像診断では、身体構造の画像を得ることができますが、分子イメージングでは、身体がどのように機能しているかを確認し、化学的および生物学的過程を測定することができます。分子イメージングには、MRIや核医学といった画像診断手法が含まれ、疾患を初期段階で捉えることや、腫瘍の正確な位置の特定などに役立ちます。分子イメージング学分野では、これらのイメージング手法の開発・評価だけでなく、画像解析による新たな診断指標の開発や予後との関連を明らかにすることを目標としています。

メンバー

教員

放射線学科

• Takatsu, Y., Ueyama, T., Iwasaki, T. et al. Simulation of time–intensity curve based on k-space filling in breast dynamic contrast-enhanced three-dimensional magnetic resonance imaging. Radiol Phys Technol (2024). https://doi.org/10.1007/s12194-024-00793-y 
• Shiiba, T., Watanabe, M. Stability of radiomic features from positron emission tomography images: a phantom study comparing advanced reconstruction algorithms and ordered subset expectation maximization. Phys Eng Sci Med (2024). https://doi.org/10.1007/s13246-024-01416-x
• Shimozono, T., Shiiba, T. & Takano, K. Radiomics score derived from T1-w/T2-w ratio image can predict motor symptom progression in Parkinson’s disease. Eur Radiol (2024). https://doi.org/10.1007/s00330-024-10886-2

• Takatsu Y, Nakamura M, Suzuki Y, Miyati T. Dependence of apparent diffusion coefficient on slice position in magnetic resonance diffusion imaging. Magn Reson Imaging. 2023;99:41-47. doi:10.1016/j.mri.2023.01.009
• Naoya Kuga, Takuro Shiiba, Tatsuhiko Sato, Shintaro Hashimoto & Yasuyoshi Kuroiwa. Experimental and computational verifications of the dose calculation accuracy of PHITS for high-energy photon beam therapy, Journal of Nuclear Science and Technology, DOI: 10.1080/00223131.2023.2275737

• Takatsu, Y., Yoshida, R., Yamatani, Y. et al. Can magnetic resonance imaging after cranioplasty using titanium mesh detect brain tumors?. Phys Eng Sci Med (2022). https://doi.org/10.1007/s13246-022-01200-9
• Yasuo Takatsu, Masafumi Nakamura, Hajime Sagawa, Yuichi Suzuki, Nobuyuki Mori, Shunichi Motegi, Tosiaki Miyati. Differences in apparent diffusion coefficients between normal brain echo- planar images and turbo spin-echo diffusion-weighted images with distortion correction. 149:110202, 2022.
• Yasuo Takatsu, Kenichirou Yamamura, Yuya Yamatani, Daisuke Takahashi, Rei Yoshida, Masaki Asahara, Michitaka Honda, Tosiaki Miyati. Echo‑planar imaging is superior to fast spin‑echo diffusion‑weighted imaging for cranioplasty using titanium mesh in brain magnetic resonance imaging: a phantom study. Radiological Physics and Technology (in press),
• Shiiba T, Sekikawa Y, Tateoka S, et al. Verification of the effect of acquisition time for SwiftScan on quantitative bone single-photon emission computed tomography using an anthropomorphic phantom. EJNMMI Phys. 2022;9(1):48. Published 2022 Jul 30. doi:10.1186/s40658-022-00477-9
• Shiiba, T., Takano, K., Takaki, A. et al. Dopamine transporter single-photon emission computed tomography-derived radiomics signature for detecting Parkinson’s disease. EJNMMI Res 12, 39 (2022). https://doi.org/10.1186/s13550-022-00910-1

• Yasuo Takatsu, Masafumi Nakamura, Satoshi Kobayashi, Tosiaki Miyati.Prediction of sufficient liver enhancement in the gadoxetate disodium-enhanced hepatobiliary phase by transitional phase images and albumin–bilirubin grade. Magnetic Resonance in Medical Sciences, 20:152-159, 2021,
• Yasuo Takatsu, Tsuyoshi Ueyama, Takahiro Iwasaki, Masaki Asahara, Michitaka Honda, Tosiaki Miyati. Effects of k-space orders on the time-intensity curves in dynamic contrast-enhanced magnetic resonance imaging of the breast based on simulation study. Magnetic Resonance Imaging. 79:85-96, 2021,
• Yasuo Takatsu, Rei Yoshida, Kenichirou Yamamura, Yuya Yamatani, Tsuyoshi Ueyama, Tetsuya Kimura, Yuriko Nohara, Tomohiro Sahara, Kengo Nishiyama, Tosiaki Miyati. Three-dimensional gradient echo sequence is useful for suppressing the radiofrequency shielding effect of a titanium mesh. Magnetic Resonance in Medical Sciences, 20:182-189, 2021,
• Yasuo Takatsu, Masafumi Nakamura, Takanobu Yamashiro, Atsushi Ikemoto, Satoshi Sawa, Masanobu Nakamura, Tosiaki Miyati. Evaluation of contrast and denoising effects related to imaging parameters of compressed sensitivity encoding in contrast‑enhanced magnetic resonance imaging. Radiological Physics and Technology, 14:193-202, 2021,
• Yasuo Takatsu, Masafumi Nakamura, Toshiki Shiozaki, Shoko Narukami, Tosiaki Miyati, Satoshi Kobayashi. Assessment of the cut-off value of quantitative livereportal vein contrast ratio in the hepatobiliary phase of liver MRI. Clinical Radiology, 76:551.e17-551.e24, 2021,
• Eisuke Sato, Kei Fukuzawa, Hiroyuki Takashima, Yuya Yamatani, Yasuo Takatsu, Junichi Hata, Keigo Hikishima, Kenta Miwa. Evaluation of a polyethylene glycol phantom for measuring apparent diffusion coefficients using three 3.0 T MRI systems. Applied Magnetic Resonance, 52:619-631, 2021,

• Shiiba, T, Arimura, Y, Nagano M, Takahashi T, Takaki A. Improvement of classification performance of Parkinson's disease using shape features for machine learning on dopamine transporter single photon emission computed tomography. PLoS ONE, 15(1), e0228289, 2020.
• Takano K, Yamada M. Contrast-enhanced magnetic resonance imaging evidence for the role of astrocytic aquaporin-4 water channels in glymphatic influx and interstitial solute transport. Magnetic Resonance Imaging, 71,11–16, 2020.
• Yasuo Takatsu, Hajime Sagawa, Masafumi Nakamura, Yuichi Suzuki, Tosiaki Miyati. Diffusion-weighted breast magnetic resonance imaging with distortion correction using non-rigid image registration: A clinical study. Radiological Physics and Technology, 13:210–218, 2020,

• Shirakawa, S., K. Tsukamoto, H. Azuma, K. Nakashima, M. Tsujimoto, K. Takano, and M. Yamada. Nonuniform sampling pitch acquisition method in myocardial single-photon emission computed tomography. Nuclear medicine communications, 40(8), 792–801, 2019.

•  Takuro Shiiba, Masanori Watanabe. Stability of radiomic features from positron emission tomography images using advanced reconstruction algorithms. SNMMI2024, June 8–11, Toronto, Canada

• Yasuo Taktsu. Contrast-Free Tumor Classification in Liver MRI. ICMRI2023, Nov. 3–4, Seoul, Korea. 

• Takuya Shimozono and Takuro Shiiba. Magnetic Resonance T1w/T2w Ratio-Based Radiomics Score for Predicting Clinical Motor Outcomes in Parkinson’s Disease. AAPM 65th Annual Meeting, July 23–27, Houston, TX, USA

• Takuro Shiiba. Does radiomics score obtained from dopamine transporter SPECT reflect the severity of Parkinson's disease? SNMMI2023, June 24–27, Chicago IL, USA

• 下薗卓也，椎葉拓郎，伊藤柊二，高野一輝．T1強調/T2強調比画像のradiomics特徴量を用いたパーキンソン病の運動症状の進行度予測の可能性．第79回日本放射線技術学会総会学術大会，2023年4月，横浜，パシフィコ横浜
  

• Yasuo Takatsu, Masafumi Nakamura, Satoshi Kobayashi, Tosiaki MiyatiInvestigation of new assessment method for the liver magnetic resonance imaging. ISMRM & SMRT Virtual Conference & Exhibition. 2021.05.15-20 On line

• Yasuo Takatsu, Kenichiro Yamamura, Yuya Yamatani, Daisuke Takahashi, Rei Yoshida, Masaki Asahara, Michitaka Honda, Tosiaki Miyati. Influence of Radiofrequency-Shielding Effect of a Titanium Mesh in Magnetic Resonance Diffusion-Weighted Imaging. the 9th International Congress on MRI & 26th Annual Scientific Meeting of KSMRM (ICMRI 2021) 2021.11.05-06 Seoul

• 伊藤柊二，椎葉拓郎，髙野一輝ドパミントランスポータSPECTにおける脳テンプレートを用いた3次元radiomics特徴量の有用性．第41回日本核医学技術学会総会学術大会，2021年11月4日–6日，名古屋市．
• 椎葉拓郎．ドパミントランスポータSPECT画像への人工知能応用の可能性．第49回日本放射線技術学会秋季学術大会第83回核医学部会，2021年10月15–17日，熊本市．
• Takuro Shiiba, Yuya Sekikawa, Takuro Shiiba, Shinji Tateoka, Nobutaka Shinohara, Yuuki Inoue, Yasuyoshi Kuroiwa, Yuya Sekikawa, Takashi Tanaka, Yasushi Kihara, Takuroh Imamura. Impact of SwiftScan technique on quantitative bone single photon emission computed tomography. Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2021, June 11-15, 2021, WEB.
• Yuya Sekikawa, Takuro Shiiba, Shinji Tateoka, Nobutaka Shinohara, Yuuki Inoue, Yasuyoshi Kuroiwa, Takashi Tanaka, Yasushi Kihara, Takuroh Imamura. The impact of acquisition time on quantitative bone single photon emission computed tomography using the SwiftScan technique. Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2021, June 11-15, 2021, WEB.

• Takuro Shiiba, Masahiro Harada, Kaito Ijima. Feasibility of Applying Super-Resolution Techniques Using Deep Learning to SPECT Images. European congress of radiology (ECR) 2021, March 3–7, 2021, WEB.
• Takuro Shiiba, Akihiro Takaki. Feasibility of Improvement of Prediction Performance for Motor Function Prognosis in Parkinson's Disease Using Dopamine Transporter SPECT Image Features. 第76回日本放射線技術学会総会学術大会，2020年5月23日–6月17日，WEB.
• Yasuo Takatsu, Hajime Sagawa, Masafumi Nakamura, Yuichi Suzuki, Tosiaki Miyati. Effectiveness of distortion correction for diffusion-weighted imaging using clinical images. ISMRM & SMRT Virtual Conference & Exhibition, 2020.08.08-14　On line

• Yasuo Takatsu, Rei Yoshida, Kinichiro Yamamura, Yuya Yamatani, Tosiaki Miyati. Useful sequence for suppressing the radiofrequency shielding effect of a titanium mesh. ISMRM & SMRT Virtual Conference & Exhibition, 2020.08.08-14　On line

• Takuro Shiiba, Akihiro Takaki. Comparison of diagnostic performance of deep convolutional neural network using fine-tuning and feature extraction on dopamine transporter single photon emission tomography images. Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2019, June 22–25,2019, Anaheim, CA, USA.
• 椎葉拓郎，中村優花，中村太一，高木昭浩. Development of classification method using automatic shape extraction for dopamine transporter SPECT image. 第75回日本放射線技術学会総会学術大会，2019年4月11日–14日，横浜市.

• 高津安男 編集：MR画像検査学．2023年3月31日，MEDICAL VIEW．
• 椎葉拓郎（分担執筆）：放射線安全管理学．高橋康幸 監修.  第12章 B.各種モダリティにおける放射線防護，4.核医学検査，2023年11月，南江堂.
• 椎葉拓郎（分担執筆）：診療放射線技師臨床実習テキスト. 遠藤啓吾 監修. 第3部 第1章 病棟撮影，第8章 核医学, 2020年6月, 文光堂.
• 椎葉拓郎（分担執筆）：新核医学技術総論　技術編．日本核医学技術学会編．第4部第2章画　像解析と表示, 195–207, 2020年3月，山代出版.

• 藤田医科大学までのアクセス ⇒ 藤田学園ホームページ

• 分子イメージング学分野へのアクセス ⇒ 大学7号館4階，大学6号館5階