医療科学部 研究推進ユニット
先進診断システム開発分野

ニュース&トピックス

• 2022年2月23日

• 2022年2月4日

• 2021年11月7日

• 2021年10月15日

分野紹介

我が国では急速に進む少子高齢化に加え、医学技術の進歩による高度化やニーズの増大によって医療費が年ごとに増加しており、国民の負担軽減のためにどう対処するかが重大な課題となっています。そのような現状の中で「先制医療」の実現が期待されています。
先制医療とは、病気が発症するよりも早期（以下、不健康とする）に高い精度で発症予測・診断を行い、発症前に治療的介入を実施することによって疾病を予防する、あるいは発症を遅らせるという、究極の個の医療であり新しい医療のパラダイムシフトです。すなわち、皆さんが病気にならないうちに新しい診断技術を用いて、個人の不健康度を診断（先制診断）し、何らかの手段（先制攻撃）を講じることで病気にならないようにしようという夢のような概念です。
先進診断システム開発分野は、この先制医療を実現すべく、がんなどの生活習慣病や、ストレスによるうつ病などの精神疾患に対する診断薬開発を行います。そのほかに、近年ではがんやリウマチなどの自己免疫疾患に著効を呈する、根治も夢ではない薬がたくさん開発されていますが、薬価が非常に高く、治療コストが１人あたり数千万円になることもあります。しかし、薬は残念ながら服用した全員に効果があるとは限りません。そこで、我々は、このような薬に対して、薬剤投与前に薬効・副作用の予測を可能とする診断技術の開発を産学連携により行います。

メンバー

教員

医療検査学科

1. Kubota H, Kunisawa K, Wulaer B, Hasegawa M, Kurahashi H, Sakata T, Tezuka H,Kugita M, Nagao S, Nagai T, Furuyashiki T, Narumiya S, Saito K, Nabeshima T,Mouri A. High salt induces cognitive impairment via the interaction of　angiotensin II-AT1 and prostaglandin E2-EP1 systems. Br J Pharmacol. 2023 Apr 19.
2. Ando T, Hoshi M, Tezuka H, Ito H, Nakamoto K, Yamamoto Y, Saito K. Absence of indoleamine 2,3 dioxygenase 2 promotes liver regeneration after partial hepatectomy in mice. Mol Med Rep. 2023 Feb;27(2):24.
3. Phu Ly MH, Nguyen CT, Nguyen TV, Ngan Nguyen TT, Nabeshima T, Adungo F, Takamatsu Y, Huy NT, Mai Le TQ, Morita K, Hasebe F, Moi ML. Differential Infectivity of Human Neural Cell Lines by a Dengue Virus Serotype-3 Genotype-III with a Distinct Nonstructural Protein 2A (NS2A) Amino Acid Substitution Isolated from the Cerebrospinal Fluid of a Dengue Encephalitis Patient. Can J Infect Dis Med Microbiol. 2023 Jan 17;2023:2635383.

1. Sakai A, Morishita T, Suzumura K, Hanatate F, Yoshikawa T, Sasaki N, Lee S, Fujita K, Hara T, Araki H, Tagami A, Murayama M, Yamada R, Iwata A, Sobajima T,Kasahara Y, Matsuzawa Y, Takemura M, Yamamoto Y, Fujigaki H, Saito K, Tsurumi H,　Matsunami H. The Trajectory of the COVID-19 Vaccine Antibody Titers Over Time and the Association of Mycophenolate Mofetil in Solid Organ Transplant Recipients. Transplant Proc. 2022 Dec;54(10):2638-2645.
2. Kubota H, Kunisawa K, Niijima M, Hirakawa M, Mori Y, Hasegawa M, Fujigaki S, Fujigaki H, Yamamoto Y, Saito K, Nabeshima T, Mouri A. Deficiency of kynurenine 3-monooxygenase exacerbates impairment of prepulse inhibition induced by　phencyclidine. Biochem Biophys Res Commun. 2022 Nov 12;629:142-151.
3. Kunisawa K, Shan J, Lu Q, Yang Y, Kosuge A, Kurahashi H, Saito K, Zou L, Nabeshima T, Mouri A. Loureirin C and Xanthoceraside Attenuate Depression-Like Behaviors and Expression of Interleukin-17 in the Prefrontal Cortex Induced by Chronic Unpredictable Mild Stress in Mice. Neurochem Res. 2022 Sep;47(9):2880-2889.
4. Yang Y, Mouri A, Lu Q, Kunisawa K, Kubota H, Hasegawa M, Hirakawa M, Mori Y, Libo Z, Saito K, Nabeshima T. Loureirin C and Xanthoceraside Prevent Abnormal Behaviors Associated with Downregulation of Brain Derived Neurotrophic Factor and AKT/mTOR/CREB Signaling in the Prefrontal Cortex Induced by Chronic Corticosterone Exposure in Mice. Neurochem Res. 2022 Sep;47(9):2865-2879.
5. Ishida H, Yamamoto Y, Saito M, Ishihara Y, Fujita T, Ishida M, Kato Y, Nohisa Y, Matsunami H, Takemura M, Hata T, Ito H, Saito K. Validation of the Martin method to estimate low-density lipoprotein cholesterol concentrations in Japanese populations and a modified method for laboratory information system application. Ann Clin Biochem. 2022 Sep;59(5):316-323.
6. Nguyen BT, Shin EJ, Jeong JH, Sharma N, Nah SY, Ko SK, Byun JK, Lee Y, Lei XG, Kim DJ, Nabeshima T, Kim HC. Ginsenoside Re attenuates memory impairments in aged Klotho deficient mice via interactive modulations of angiotensin II AT1 receptor, Nrf2 and GPx-1 gene. Free Radic Biol Med. 2022 Aug 20;189:2-19.
7. Okamoto A, Fujigaki H, Iriyama C, Goto N, Yamamoto H, Mihara K, Inaguma Y, Miura Y, Furukawa K, Yamamoto Y, Akatsuka Y, Kasahara S, Miyao K, Tokuda M, Sato S, Mizutani Y, Osawa M, Hattori K, Iba S, Kajiya R, Okamoto M, Saito K, Tomita　A. CD19-positive lymphocyte count is critical for acquisition of anti-SARS-CoV-2 IgG after vaccination in B-cell lymphoma. Blood Adv. 2022 Jun 14;6(11):3230-3233.
8. Lee MT, Mouri A, Kubota H, Lee HJ, Chang MH, Wu CY, Knutson DE, Mihovilovic M, Cook J, Sieghart W, Nabeshima T, Chiou LC. Targeting α6GABA_A receptors as a novel therapy for schizophrenia: A proof-of-concept preclinical study using various animal models. Biomed Pharmacother. 2022 Jun;150:113022.
9. Yamazaki K, Hoshi M, Tezuka H, Morita N, Hirayama M, Sato F, Yoshida S, Saito K. D allose enhances the efficacy of hydroxychloroquine against Lewis lung carcinoma cell growth by inducing autophagy. Oncol Rep. 2022 Jun;47(6):117.

1. Blachier F, Blais A, Elango R, Saito K, Shimomura Y, Kadowaki M, Matsumoto H. Tolerable amounts of amino acids for human supplementation: summary and lessons from published peer-reviewed studies. Amino Acids. 2021 Sep;53(9):1313-1328.
2. Ishida H, Takemura M, Suetsugu A, Naiki T, Tanaka T, Eiichi T, Serrero G, Matsunami H, Yamamoto Y, Saito K. Serum GP88 as a predictive biomarker for hepatocellular carcinoma in patients with viral hepatitis C after direct-acting antiviral agents. Ann Clin Biochem. 2021 Aug 11:45632211036723.
3. Hoshi M, Kubo H, Ando T, Tashita C, Nakamoto K, Yamamoto Y, Tezuka H, Saito K. 3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice. Immunohorizons. 2021 Jun 28;5(6):523-534.
4. Kosuge A, Kunisawa K, Arai S, Sugawara Y, Shinohara K, Iida T, Wulaer B, Kawai T, Fujigaki H, Yamamoto Y, Saito K, Nabeshima T, Mouri A. Heat-sterilized Bifidobacterium breve prevents depression-like behavior and interleukin-1β expression in mice exposed to chronic social defeat stress. Brain Behav Immun. 2021 Aug;96:200-211.
5. Hayakawa T, Teramoto A, Kiriyama Y, Tsukamoto T, Yamada A, Saito K, Fujita H. Development of Pathological Diagnosis Support System Using Micro-computed Tomography. Acta Histochem Cytochem. 2021 Apr 28;54(2):49-56.
6. Fujigaki H, Inaba M, Osawa M, Moriyama S, Takahashi Y, Suzuki T, Yamase K, Yoshida Y, Yagura Y, Oyamada T, Takemura M, Doi Y, Saito K. Comparative Analysis of Antigen-Specific Anti-SARS-CoV-2 Antibody Isotypes in COVID-19 Patients. J Immunol. 2021 May 15;206(10):2393-2401.
7. Teramoto A, Yamada A, Tsukamoto T, Kiriyama Y, Sakurai E, Shiogama K, Michiba A, Imaizumi K, Saito K, Fujita H. Mutual stain conversion between Giemsa and Papanicolaou in cytological images using cycle generative adversarial network. Heliyon. 2021 Feb 24;7(2):e06331.
8. Wulaer B, Kunisawa K, Tanabe M, Yanagawa A, Saito K, Mouri A, Nabeshima T. Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice. Mol Brain. 2021 Feb 28;14(1):43
9. Mori Y, Mouri A, Kunisawa K, Hirakawa M, Kubota H, Kosuge A, Niijima M, Hasegawa M, Kurahashi H, Murakami R, Hoshi M, Nakano T, Fujigaki S, Fujigaki H, Yamamoto Y, Nabeshima T, Saito K. Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid. Behav Brain Res. 2021 May 7;405:113191.
10. Yabe K, Yamamoto Y, Takemura M, Hara T, Tsurumi H, Serrero G, Nabeshima T, Saito K. Progranulin depletion inhibits proliferation via the transforming growth factor beta/SMAD family member 2 signaling axis in Kasumi-1 cells. Heliyon. 2021 Jan 8;7(1):e05849.
11. Toda R, Teramoto A, Tsujimoto M, Toyama H, Imaizumi K, Saito K, Fujita H. Synthetic CT image generation of shape-controlled lung cancer using semi-conditional InfoGAN and its applicability for type classification. Int J Comput Assist Radiol Surg. 2021 Feb;16(2):241-251
12. Sumitomo M, Takahara K, Zennami K, Nagakawa T, Maeda Y, Shiogama K, Yamamoto Y, Muto Y, Nukaya T, Takenaka M, Fukaya K, Ichino M, Sasaki H, Saito K, Shiroki R. Tryptophan 2,3-dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma. Cancer Sci. 2021 Mar;112(3):1038-1047.
13. Wulaer B, Kunisawa K, Kubota H, Suento WJ, Saito K, Mouri A, Nabeshima T. Prefrontal cortex, dorsomedial striatum, and dentate gyrus are necessary in the object-based attention test in mice. Mol Brain. 2020 Dec 14;13(1):171
14. Suento WJ, Kunisawa K, Wulaer B, Kosuge A, Iida T, Fujigaki S, Fujigaki H, Yamamoto Y, Tanra AJ, Saito K, Mouri A, Nabeshima T. Prefrontal cortex miR-874-3p prevents lipopolysaccharide-induced depression-like behavior through inhibition of indoleamine 2,3-dioxygenase 1 expression in mice. J Neurochem. 2021 Jun;157(6):1963-1978

1. Kimura R, Teramoto A, Ohno T, Saito K, Fujita H. Virtual digital subtraction angiography using multizone patch-based U-Net. Phys Eng Sci Med. 2020 Dec;43(4):1305-1315
2. Fujigaki H, Takemura M, Osawa M, Sakurai A, Nakamoto K, Seto K, Fujita T, Hata T, Akiyama H, Doi Y, Saito K. Reliability of serological tests for COVID-19: comparison of three immunochromatography test kits for SARS-CoV-2 antibodies. Heliyon. 2020 Sep 10;6(9):e04929.
3. Fujii K, Yamamoto Y, Mizutani Y, Saito K, Seishima M. Indoleamine 2,3-Dioxygenase 2 Deficiency Exacerbates Imiquimod-Induced Psoriasis-Like Skin Inflammation. Int J Mol Sci. 2020 Aug 1;21(15):5515.
4. Onishi Y, Teramoto A, Tsujimoto M, Tsukamoto T, Saito K, Toyama H, Imaizumi K, Fujita H. Investigation of pulmonary nodule classification using multi-scale residual network enhanced with 3DGAN-synthesized volumes. Radiol Phys Technol. 2020 Jun;13(2):160-169.
5. Hoshi M, Osawa Y, Nakamoto K, Morita N, Yamamoto Y, Ando T, Tashita C, Nabeshima T, Saito K. Kynurenine produced by indoleamine 2,3-dioxygenase 2 exacerbates acute liver injury by carbon tetrachloride in mice. Toxicology. 2020 May 30;438:152458.
6. Wulaer B, Kunisawa K, Hada K, Jaya Suento W, Kubota H, Iida T, Kosuge A, Nagai T, Yamada K, Nitta A, Yamamoto Y, Saito K, Mouri A, Nabeshima T. Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus. J Neurochem. 2021 May;157(3):642-655.
7. Tashita C, Hoshi M, Hirata A, Nakamoto K, Ando T, Hattori T, Yamamoto Y, Tezuka H, Tomita H, Hara A, Saito K. Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice. World J Gastroenterol. 2020 Mar 7;26(9):918-932.
8. Teramoto A, Tsukamoto T, Yamada A, Kiriyama Y, Imaizumi K, Saito K, Fujita H. Deep learning approach to classification of lung cytological images: Two-step training using actual and synthesized images by progressive growing of generative adversarial networks. PLoS One. 2020 Mar 5;15(3):e0229951.
9. Murakami Y, Imamura Y, Saito K, Sakai D, Motoyama J. Author Correction: Altered kynurenine pathway metabolites in a mouse model of human attention-deficit hyperactivity/autism spectrum disorders: A potential new biological diagnostic marker. Sci Rep. 2020 Feb 28;10(1):4034.
10. Teramoto A, Yamada A, Tsukamoto T, Imaizumi K, Toyama H, Saito K, Fujita H. Decision Support System for Lung Cancer Using PET/CT and Microscopic Images. Adv Exp Med Biol. 2020;1213:73-94
11. Sakurai M, Yamamoto Y, Kanayama N, Hasegawa M, Mouri A, Takemura M, Matsunami H, Miyauchi T, Tokura T, Kimura H, Ito M, Umemura E, Boku AS, Nagashima W, Tonoike T, Kurita K, Ozaki N, Nabeshima T, Saito K. Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder. Sci Rep. 2020 Feb 6;10(1):1961.
12. Phan DH, Shin EJ, Jeong JH, Tran HQ, Sharma N, Nguyen BT, Jung TW, Nah SY, Saito K, Nabeshima T, Kim HC. Lithium attenuates d-amphetamine-induced hyperlocomotor activity in mice via inhibition of interaction between cyclooxygenase-2 and indoleamine-2,3-dioxygenase. Clin Exp Pharmacol Physiol. 2020 May;47(5):790-797.
13. Matsubara N, Teramoto A, Saito K, Fujita H. Bone suppression for chest X-ray image using a convolutional neural filter. Australas Phys Eng Sci Med. 2019 Nov 26.
14. Tran HQ, Shin EJ, Saito K, Tran TV, Phan DH, Sharma N, Kim DW, Choi SY, Jeong JH, Jang CG, Cheong JH, Nabeshima T, Kim HC. Indoleamine-2,3-dioxygenase-1 is a molecular target for the protective activity of mood stabilizers against mania-like behavior induced by d-amphetamine. Food Chem Toxicol. 2020 Feb;136:110986.
15. Onishi Y, Teramoto A, Tsujimoto M, Tsukamoto T, Saito K, Toyama H, Imaizumi K, Fujita H. Multiplanar analysis for pulmonary nodule classification in CT images using deep convolutional neural network and generative adversarial networks. Int J Comput Assist Radiol Surg. 2020 Jan;15(1):173-178.
16. Sakai A, Onishi Y, Matsui M, Adachi H, Teramoto A, Saito K, Fujita H. A method for the automated classification of benign and malignant masses on digital breast tomosynthesis images using machine learning and radiomic features. Radiol Phys Technol. 2020 Mar;13(1):27-36.

1. Murakami Y, Imamura Y, Saito K, Sakai D, Motoyama J. Altered kynurenine pathway metabolites in a mouse model of human attention-deficit hyperactivity/autism spectrum disorders: A potential new biological diagnostic marker. Sci Rep. 2019 Sep 12;9(1):13182.
2. Yamasuge W, Yamamoto Y, Fujigaki H, Hoshi M, Nakamoto K, Kunisawa K, Mouri A, Nabeshima T, Saito K. Indoleamine 2,3-dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma. Cancer Sci. 2019 Oct;110(10):3061-3067.
3. Yoshida Y, Fujigaki H, Kato K, Yamazaki K, Fujigaki S, Kunisawa K, Yamamoto Y, Mouri A, Oda A, Nabeshima T, Saito K. Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues. Sci Rep. 2019 Jul 15;9(1):10243.
4. Lu Q, Mouri A, Yang Y, Kunisawa K, Teshigawara T, Hirakawa M, Mori Y, Yamamoto Y, Libo Z, Nabeshima T, Saito K. Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression. Behav Brain Res. 2019 Oct 17;372:112053.
5. Kimura A, Takemura M, Yamamoto Y, Hayashi Y, Saito K, Shimohata T. Cytokines and biological markers in autoimmune GFAP astrocytopathy: The potential role for pathogenesis and therapeutic implications. J Neuroimmunol. 2019 Sep 15;334:576999.
6. Teshigawara T, Mouri A, Kubo H, Nakamura Y, Shiino T, Okada T, Morikawa M, Nabeshima T, Ozaki N, Yamamoto Y, Saito K. Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms. J Affect Disord. 2019 Aug 1;255:168-176.
7. Minoura N, Teramoto A, Ito A, Yamamuro O, Nishio M, Saito K, Fujita H. A complementary scheme for automated detection of high-uptake regions on dedicated breast PET and whole-body PET/CT. Radiol Phys Technol. 2019 Sep;12(3):260-267.
8. Miyauchi T, Tokura T, Kimura H, Ito M, Umemura E, Sato Boku A, Nagashima W, Tonoike T, Yamamoto Y, Saito K, Kurita K, Ozaki N. Effect of antidepressant treatment on plasma levels of neuroinflammation-associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region. Hum Psychopharmacol. 2019 Jul;34(4):e2698.
9. Tanaka S, Oya-Ito T, Murakami Y, Saito K, Furuta S, Yu Y, Imaeda M, Kunimoto S, Ozaki N. Decline of Plasma Concentrations of Interleukin-18 in Severely Malnourished Patients with Anorexia Nervosa: Exploratory Analysis. Nutrients. 2019 Mar 3;11(3):540.
10. Kawaguchi K, Sakurai M, Yamamoto Y, Suzuki E, Tsuda M, Kataoka TR, Hirata M, Nishie M, Nojiri T, Kumazoe M, Saito K, Toi M. Alteration of specific cytokine expression patterns in patients with breast cancer. Sci Rep. 2019 Feb 27;9(1):2924.
11. Fujigaki H, Mouri A, Yamamoto Y, Nabeshima T, Saito K. Linking phencyclidine intoxication to the tryptophan-kynurenine pathway: Therapeutic implications for schizophrenia. Neurochem Int. 2019 May;125:1-6.
12. Onishi Y, Teramoto A, Tsujimoto M, Tsukamoto T, Saito K, Toyama H, Imaizumi K, Fujita H. Automated Pulmonary Nodule Classification in Computed Tomography Images Using a Deep Convolutional Neural Network Trained by Generative Adversarial Networks. Biomed Res Int. 2019 Jan 2;2019:6051939.
13. Teramoto A, Tsujimoto M, Inoue T, Tsukamoto T, Imaizumi K, Toyama H, Saito K, Fujita H. Automated Classification of Pulmonary Nodules through a Retrospective Analysis of Conventional CT and Two-phase PET Images in Patients Undergoing Biopsy. Asia Ocean J Nucl Med Biol. 2019 Winter;7(1):29-37.

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