Department of Biochemistry
Fujita Health University
School of Medicine
5th floor, Building No. 11


 

Publications of Harada lab (-2018)


»Go back to Publications (2019 and later)


2019

Fujii R, Yamada H, Munetsuna E, Yamazaki M, Mizuno G, Tsuboi Y, Ohashi K, Ishikawa H, Ando Y, Hagiwara C, Maeda K, Hashimoto S, Hamajima N, Suzuki K. Dietary vegetable intake is inversely associated with ATP-binding cassette protein A1 (ABCA1) DNA methylation levels among Japanese women. Nutrition. 2019;65:1-5. doi: 10.1016/j.nut.2019.02.010.

Fujii R, Yamada H, Munetsuna E, Yamazaki M, Ohashi K, Ishikawa H, Maeda K, Hagiwara C, Ando Y, Hashimoto S, Hamajima N, Suzuki K. Associations of circulating microRNAs (miR-17, miR-21, and miR-150) and chronic kidney disease in a Japanese population. J Epidemiol. 2019 Mar 23. doi: 10.2188/jea.JE20180233. [Epub ahead of print]

Munetsuna E, Yamada H, Yamazaki M, Ando Y, Mizuno G, Hattori Y, Sadamoto N, Ishikawa H, Ohta Y, Fujii R, Suzuki K, Hashimoto S, Ohashi K. Maternal high-fructose intake increases circulating corticosterone levels via decreased adrenal corticosterone clearance in adult offspring. J Nutr Biochem. 2019;67:44-50. doi: 10.1016/j.jnutbio.2019.01.016.

Kondo M, Yamada H, Munetsuna E, Yamazaki M, Hatta T, Iwahara A, Ohashi K, Ishikawa H, Tsuboi Y, Inoue T, Fujii R, Suzuki K. Associations of serum microRNA-20a, -27a, and -103a with cognitive function in a Japanese population: The Yakumo study. Arch Gerontol Geriatr. 2019;82:155-160. doi: 10.1016/j.archger.2019.01.007.

Ishikawa H, Yamada H, Kondo K, Ota T, Yamazaki M, Ando Y, Mizuno G, Munetsuna E, Suzuki K, Teradaira R, Ohashi K. Establishment of a simpler method for measuring HDL-microRNAs. Ann Clin Biochem. 2019;56:49-55. doi: 10.1177/0004563218775770.

2018

Diano S, Horvath TL, Mor G, Register T, Adams M, Harada N, Naftolin F. Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects. Menopause. 2018; 25:1201-1207. doi: 10.1097/GME.0000000000001219.

Ohe K, Miyajima S, Tanaka T, Hamaguchi Y, Harada Y, Horita Y, Beppu Y, Ito F, Yamasaki T, Terai H, Mori M, Murata Y, Tanabe M, Abe I, Ashida K, Kobayashi K, Enjoji M, Nomiyama T, Yanase T, Harada N, Utsumi T, Mayeda A. HMGA1a Induces Alternative Splicing of the Estrogen Receptor-αlpha Gene by Trapping U1 snRNP to an Upstream Pseudo-5' Splice Site. Front Mol Biosci. 2018;5:52. doi: 10.3389/fmolb.2018.00052.

Hayashi T, Hikichi M, Yukitake J, Wakatsuki T, Nishio E, Utsumi T, Harada N. Forskolin increases the effect of everolimus on aromatase inhibitor-resistant breast cancer cells. Oncotarget. 2018;9:23451-23461. doi: 10.18632/oncotarget.25217.

Ohe K, Miyajima S, Abe I, Tanaka T, Hamaguchi Y, Harada Y, Horita Y, Beppu Y, Ito F, Yamasaki T, Terai H, Mori M, Murata Y, Tanabe M, Ashida K, Kobayashi K, Enjoji M, Yanase T, Harada N, Utsumi T, Mayeda A. HMGA1a induces alternative splicing of estrogen receptor alpha in MCF-7 human breast cancer cells. J Steroid Biochem Mol Biol. 2018;182:21-26. doi: 10.1016/j.jsbmb.2018.04.007.

Munetsuna E, Yamada H, Yamazaki M, Ando Y, Mizuno G, Ota T, Hattori Y, Sadamoto N, Suzuki K, Ishikawa H, Hashimoto S, Ohashi K. Maternal fructose intake disturbs ovarian estradiol synthesis in rats. Life Sci. 2018;202:117-123. doi: 10.1016/j.lfs.2018.04.006.

Tsuboi Y, Yamada H, Munetsuna E, Yamazaki M, Mizuno G, Murase Y, Ohashi K, Ishikawa H, Kondo M, Inoue T, Hashimoto S, Hamajima N, Suzuki K. Relationship between Long Interspersed Nuclear Element-1 DNA Methylation in Leukocytes and Dyslipidemia in the Japanese General Population. J Atheroscler Thromb. 2018;25:1231-1239. doi: 10.5551/jat.43570.

Yamazaki M, Yamada H, Munetsuna E, Ishikawa H, Mizuno G, Mukuda T, Mouri A, Nabeshima T, Saito K, Suzuki K, Hashimoto S, Ohashi K. Excess maternal fructose consumption impairs hippocampal function in offspring via epigenetic modification of BDNF promoter. FASEB J. 2018;32:2549-2562. doi: 10.1096/fj.201700783RR.

Munetsuna E, Yamada H, Ando Y, Yamazaki M, Tsuboi Y, Kondo M, Mizuno G, Ishikawa H, Sugimoto K, Osakabe K, Ichino N, Ohashi K, Hamajima N, Suzuki K. Association of subcutaneous and visceral fat with circulating microRNAs in a middle-aged Japanese population. Ann Clin Biochem. 2018;55:437-445. doi: 10.1177/0004563217735124.

2017

Hayashi T, Hikichi M, Yukitake J, Harada N, Utsumi T. Estradiol suppresses phosphorylation of ERα serine 167 through upregulation of PP2A in breast cancer cells. Oncol Lett. 2017 Dec;14(6):8060-8065. doi: 10.3892/ol.2017.7216. Epub 2017 Oct 18. PubMed PMID: 29344249; PubMed Central PMCID: PMC5755173.

Honma N, Saji S, Mikami T, Yoshimura N, Mori S, Saito Y, Murayama S, Harada N. Estrogen-Related Factors in the Frontal Lobe of Alzheimer's Disease Patients and Importance of Body Mass Index. Sci Rep. 2017;7:726. doi: 10.1038/s41598-017-00815-3.

Ishihara S, Kotomura N, Yamamoto N, Ochiai H. Ligation-mediated PCR with a back-to-back adapter reduces amplification bias resulting from variations in GC content. Anal Biochem. 2017;531:37-44. doi: 10.1016/j.ab.2017.05.011.

Mizuno G, Munetsuna E, Yamada H, Ando Y, Yamazaki M, Murase Y, Kondo K, Ishikawa H, Teradaira R, Suzuki K, Ohashi K. Fructose intake during gestation and lactation differentially affects the expression of hippocampal neurosteroidogenic enzymes in rat offspring. Endocr Res. 2017;42:71-77. doi: 10.1080/07435800.2016.1182186.

Ishikawa H, Yamada H, Taromaru N, Kondo K, Nagura A, Yamazaki M, Ando Y, Munetsuna E, Suzuki K, Ohashi K, Teradaira R. Stability of serum high-density lipoprotein-microRNAs for preanalytical conditions. Ann Clin Biochem. 2017;54:134-142. doi: 10.1177/0004563216647086.

2016

Hiratsuka I, Yamada H, Munetsuna E, Hashimoto S, Itoh M. Circulating MicroRNAs in Graves' Disease in Relation to Clinical Activity. Thyroid. 2016;26:1431-1440.

Yamazaki M, Munetsuna E, Yamada H, Ando Y, Mizuno G, Murase Y, Kondo K, Ishikawa H, Teradaira R, Suzuki K, Ohashi K. Fructose consumption induces hypomethylation of hepatic mitochondrial DNA in rats. Life Sci. 2016;149:146-52. doi: 10.1016/j.lfs.2016.02.020.

2015

Kotomura N, Harada N, Ishihara S. The Proportion of Chromatin Graded between Closed and Open States Determines the Level of Transcripts Derived from Distinct Promoters in the CYP19 Gene. PLoS One. 2015 May;10:e0128282. doi: 10.1371/journal.pone.0128282.

Kurokawa J, Sasano T, Kodama M, Li M, Ebana Y, Harada N, Honda S, Nakaya H, Furukawa T. Aromatase knockout mice reveal an impact of estrogen on drug-induced alternation of murine electrocardiography parameters. J Toxicol Sci. 2015 Jun;40:339-48. doi: 10.2131/jts.40.339.

Iwasa A, Arakaki R, Honma N, Ushio A, Yamada A, Kondo T, Kurosawa E, Kujiraoka S, Tsunematsu T, Kudo Y, Tanaka E, Yoshimura N, Harada N, Hayashi Y, Ishimaru N. Aromatase controls Sjögren syndrome-like lesions through monocyte chemotactic protein-1 in target organ and adipose tissue-associated macrophages. Am J Pathol. 2015;185:151-61. doi: 10.1016/j.ajpath.2014.09.006.

Munetsuna E, Kittaka A, Chen TC, Sakaki T. Metabolism and Action of 25-Hydroxy-19-nor-Vitamin D₃ in Human Prostate Cells. Vitam Horm. 2016;100:357-77. doi: 10.1016/bs.vh.2015.10.009.

Ohashi K, Munetsuna E, Yamada H, Ando Y, Yamazaki M, Taromaru N, Nagura A, Ishikawa H, Suzuki K, Teradaira R, Hashimoto S. High fructose consumption induces DNA methylation at PPARα and CPT1A promoter regions in the rat liver. Biochem Biophys Res Commun. 2015;468:185-9. doi: 10.1016/j.bbrc.2015.10.134.

Yamada H, Ohashi K, Suzuki K, Munetsuna E, Ando Y, Yamazaki M, Ishikawa H, Ichino N, Teradaira R, Hashimoto S. Longitudinal study of circulating miR-122 in a rat model of non-alcoholic fatty liver disease. Clin Chim Acta. 2015;446:267-71. doi: 10.1016/j.cca.2015.05.002.

2014

Hayashi T, Harada N. Post-translational dual regulation of cytochrome P450 aromatase at the catalytic and protein levels by phosphorylation/dephosphorylation. FEBS J. 2014;281:4830-40. doi: 10.1111/febs.13021.

Lai WA, Yeh YT, Fang WL, Wu LS, Harada N, Wang PH, Ke FC, Lee WL, Hwang JJ. Calcineurin and CRTC2 mediate FSH and TGFβ1 upregulation of Cyp19a1 and Nr5a in ovary granulosa cells. J Mol Endocrinol. 2014;53:259-70. doi: 10.1530/JME-14-0048.

Hoyk Z, Csakvari E, Gyenes A, Siklos L, Harada N, Parducz A. Aromatase and estrogen receptor beta expression in the rat olfactory bulb: Neuroestrogen action in the first relay station of the olfactory pathway? Acta Neurobiol Exp (Wars). 2014;74:1-14.

Ubuka T, Haraguchi S, Tobari Y, Narihiro M, Ishikawa K, Hayashi T, Harada N, Tsutsui K. Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis. Nat Commun. 2014;5:3061. doi: 10.1038/ncomms4061.

Ohashi K, Ando Y, Munetsuna E, Yamada H, Yamazaki M, Nagura A, Taromaru N, Ishikawa H, Suzuki K, Teradaira R. Maternal fructose consumption alters messenger RNA expression of hippocampal StAR, PBR, P450(11β), 11β-HSD, and 17β-HSD in rat offspring. Nutr Res. 2015;35:259-64. doi: 10.1016/j.nutres.2014.11.001.

Munetsuna E, Kawanami R, Nishikawa M, Ikeda S, Nakabayashi S, Yasuda K, Ohta M, Kamakura M, Ikushiro S, Sakaki T. Anti-proliferative activity of 25-hydroxyvitamin D3 in human prostate cells. Mol Cell Endocrinol. 2014;382:960-70. doi: 10.1016/j.mce.2013.11.014.

before 2013

Honda S, Wakatsuki T, Harada N. Behavioral analysis of genetically modified mice indicates essential roles of neurosteroidal estrogen. Front Endocrinol (Lausanne). 2011;2:40. doi: 10.3389/fendo.2011.00040.

Kawakami M, Harada N, Hiratsuka M, Kawai K, Nakamura Y. Dietary isothiocyanates modify mitochondrial functions through their electrophilic reaction. Biosci Biotechnol Biochem. 2005;69:2439-44.

Harada N, Honda S. Analysis of spatiotemporal regulation of aromatase in the brain using transgenic mice. J Steroid Biochem Mol Biol. 2005;95:49-55.

Yoshimura N, Harada N, Bukholm I, Kåresen R, Børresen-Dale AL, Kristensen VN. Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer. Breast Cancer Res. 2004;6:R46-55.

Harada N, Yoshimura N, Honda S. Unique regulation of expression of human aromatase in the placenta. J Steroid Biochem Mol Biol. 2003;86:327-34. Review.

Matsumoto T, Honda S, Harada N. Alteration in sex-specific behaviors in male mice lacking the aromatase gene. Neuroendocrinology. 2003 Jun;77(6):416-24. PubMed PMID: 12845227.

Kato S, Mano T, Kobayashi T, Yamazaki N, Himeno Y, Yamamoto K, Itoh M, Harada N, Nagasaka A. A calcium-deficient diet caused decreased bone mineral density and secondary elevation of estrogen in aged male rats-effect of menatetrenone and elcatonin. Metabolism. 2002;51:1230-4.

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