Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model.
Watanabe H, Murakami R, Tsumagari K, Morimoto S, Hashimoto T, Imaizumi K, Sonn I, Yamada K, Saito Y, Murayama S, Iwatsubo T, Okano H.
Stem Cell Reports. 2023 Aug 14:S2213-6711(23)00301-6. doi: 10.1016/j.stemcr.2023.08.002. Online ahead of print.
PMID: 37657448 プレスリリース

Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula.
Kobayashi H, Ueda K, Morimoto S, Ishikawa M, Leventoux N, Sasaki R, Hirokawa Y, Kokubo Y, Okano H.
Neurol Sci. 2023 Aug 24. doi: 10.1007/s10072-023-07000-7. Online ahead of print.
PMID: 37615876

A Review of Treatment Methods Focusing on Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation for Chronic Spinal Cord Injury.
Shibata T, Tashiro S, Nakamura M, Okano H, Nagoshi N.
Medicina (Kaunas). 2023 Jul 1;59(7):1235. doi: 10.3390/medicina59071235.
PMID: 37512047

Development of cochlear spiral ligament fibrocytes of the common marmoset, a nonhuman model animal.
Hosoya M, Iwabu K, Kitama T, Nishiyama T, Oishi N, Okano H, Ozawa H.
Sci Rep. 2023 Jul 21;13(1):11789. doi: 10.1038/s41598-023-39003-x.
PMID: 37479821

LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits.
Li D, Johmura Y, Morimoto S, Doi M, Nakanishi K, Ozawa M, Tsunekawa Y, Inoue-Yamauchi A, Naruse H, Matsukawa T, Takeshita Y, Suzuki N, Aoki M, Nishiyama A, Zeng X, Konishi C, Suzuki N, Nishiyama A, Harris AS, Morita M, Yamaguchi K, Furukawa Y, Nakai K, Tsuji S, Yamazaki S, Yamanashi Y, Shimada S, Okada T, Okano H, Toda T, Nakanishi M.
Nat Aging. 2023 Aug;3(8):1001-1019. doi: 10.1038/s43587-023-00464-4. Epub 2023 Jul 20.
PMID: 37474791

Cellular senescence induction leads to progressive cell death via the INK4a-RB pathway in naked mole-rats.
Kawamura Y, Oka K, Semba T, Takamori M, Sugiura Y, Yamasaki R, Suzuki Y, Chujo T, Nagase M, Oiwa Y, Fujioka S, Homma S, Yamamura Y, Miyawaki S, Narita M, Fukuda T, Sakai Y, Ishimoto T, Tomizawa K, Suematsu M, Yamamoto T, Bono H, Okano H, Miura K.
EMBO J. 2023 Aug 15;42(16):e111133. doi: 10.15252/embj.2022111133. Epub 2023 Jul 11.
PMID: 37431790

The Brain/MINDS Marmoset Connectivity Resource: An open-access platform for cellular-level tracing and tractography in the primate brain.
Skibbe H, Rachmadi MF, Nakae K, Gutierrez CE, Hata J, Tsukada H, Poon C, Schlachter M, Doya K, Majka P, Rosa MGP, Okano H, Yamamori T, Ishii S, Reisert M, Watakabe A.
PLoS Biol. 2023 Jun 29;21(6):e3002158. doi: 10.1371/journal.pbio.3002158. eCollection 2023 Jun.
PMID: 37384809

Mapping of Notch signaling in the developing organ of Corti in common marmosets.
Hosoya M, Fujioka M, Okano H, Ozawa H.
Front Neuroanat. 2023 Jun 7;17:1188886. doi: 10.3389/fnana.2023.1188886. eCollection 2023.
PMID: 37351521

Starburst amacrine cells amplify optogenetic visual restoration through gap junctions.
Katada Y, Kunimi H, Serizawa N, Lee D, Kobayashi K, Negishi K, Okano H, Tanaka KF, Tsubota K, Kurihara T.
Mol Ther Methods Clin Dev. 2023 May 12;30:1-13. doi: 10.1016/j.omtm.2023.05.011. eCollection 2023 Sep 14.
PMID: 37324975

Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms.
Shima Y, Sasagawa S, Ota N, Oyama R, Tanaka M, Kubota-Sakashita M, Kawakami H, Kobayashi M, Takubo N, Ozeki AN, Sun X, Kim YJ, Kamatani Y, Matsuda K, Maejima K, Fujita M, Noda K, Kamiyama H, Tanikawa R, Nagane M, Shibahara J, Tanaka T, Rikitake Y, Mataga N, Takahashi S, Kosaki K, Okano H, Furihata T, Nakaki R, Akimitsu N, Wada Y, Ohtsuka T, Kurihara H, Kamiguchi H, Okabe S, Nakafuku M, Kato T, Nakagawa H, Saito N, Nakatomi H.
Sci Transl Med. 2023 Jun 14;15(700):eabq7721. doi: 10.1126/scitranslmed.abq7721. Epub 2023 Jun 14.
PMID: 37315111

Mesenchymal properties of iPSC-derived neural progenitors that generate undesired grafts after transplantation.
Isoda M, Sanosaka T, Tomooka R, Mabuchi Y, Shinozaki M, Andoh-Noda T, Banno S, Mizota N, Yamaguchi R, Okano H, Kohyama J.
Commun Biol. 2023 Jun 7;6(1):611. doi: 10.1038/s42003-023-04995-9.
PMID: 37286713

Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.
Morimoto S, Takahashi S, Ito D, Daté Y, Okada K, Kato C, Nakamura S, Ozawa F, Chyi CM, Nishiyama A, Suzuki N, Fujimori K, Kondo T, Takao M, Hirai M, Kabe Y, Suematsu M, Jinzaki M, Aoki M, Fujiki Y, Sato Y, Suzuki N, Nakahara J; Pooled Resource Open-Access ALS Clinical Trials Consortium; Okano H.
Cell Stem Cell. 2023 Jun 1;30(6):766-780.e9. doi: 10.1016/j.stem.2023.04.017.
PMID: 37267913 プレスリリース

Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling.
Rashid MI, Ito T, Miya F, Shimojo D, Arimoto K, Onodera K, Okada R, Nagashima T, Yamamoto K, Khatun Z, Shimul RI, Niwa JI, Katsuno M, Sobue G, Okano H, Sakurai H, Shimizu K, Doyu M, Okada Y.
Sci Rep. 2023 May 25;13(1):8146. doi: 10.1038/s41598-023-34445-9.
PMID: 37231024

Local and long-distance organization of prefrontal cortex circuits in the marmoset brain.
Watakabe A, Skibbe H, Nakae K, Abe H, Ichinohe N, Rachmadi MF, Wang J, Takaji M, Mizukami H, Woodward A, Gong R, Hata J, Van Essen DC, Okano H, Ishii S, Yamamori T.
Neuron. 2023 May 9:S0896-6273(23)00338-0. doi: 10.1016/j.neuron.2023.04.028. Online ahead of print.
PMID: 37196659

Dissecting calvarial bones and sutures at single-cell resolution.
Li B, Li J, Fan Y, Zhao Z, Li L, Okano H, Ouchi T.
Biol Rev Camb Philos Soc. 2023 May 12. doi: 10.1111/brv.12975. Online ahead of print.
PMID: 37171117

Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients.
Nakamura R, Tohnai G, Nakatochi M, Atsuta N, Watanabe H, Ito D, Katsuno M, Hirakawa A, Izumi Y, Morita M, Hirayama T, Kano O, Kanai K, Hattori N, Taniguchi A, Suzuki N, Aoki M, Iwata I, Yabe I, Shibuya K, Kuwabara S, Oda M, Hashimoto R, Aiba I, Ishihara T, Onodera O, Yamashita T, Abe K, Mizoguchi K, Shimizu T, Ikeda Y, Yokota T, Hasegawa K, Tanaka F, Nakashima K, Kaji R, Niwa JI, Doyu M, Terao C, Ikegawa S, Fujimori K, Nakamura S, Ozawa F, Morimoto S, Onodera K, Ito T, Okada Y, Okano H, Sobue G; Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS) study group.
J Neurol Neurosurg Psychiatry. 2023 May 4:jnnp-2022-330851. doi: 10.1136/jnnp-2022-330851. Online ahead of print.
PMID: 37142397

Rapid and Robust Multi-Phenotypic Assay System for ALS Using Human iPS Cells with Mutations in Causative Genes.
Kondo T, Ebinuma I, Tanaka H, Nishikawa Y, Komiya T, Ishikawa M, Okano H.
Int J Mol Sci. 2023 Apr 10;24(8):6987. doi: 10.3390/ijms24086987.
PMID: 37108151

Multi-modal brain magnetic resonance imaging database covering marmosets with a wide age range.
Hata J, Nakae K, Tsukada H, Woodward A, Haga Y, Iida M, Uematsu A, Seki F, Ichinohe N, Gong R, Kaneko T, Yoshimaru D, Watakabe A, Abe H, Tani T, Hamda HT, Gutierrez CE, Skibbe H, Maeda M, Papazian F, Hagiya K, Kishi N, Ishii S, Doya K, Shimogori T, Yamamori T, Tanaka K, Okano HJ, Okano H.
Sci Data. 2023 Apr 27;10(1):221. doi: 10.1038/s41597-023-02121-2.
PMID: 37105968 プレスリリース

The Japan Monkey Centre Primates Brain Imaging Repository of high-resolution postmortem magnetic resonance imaging: the second phase of the archive of digital records.
Sakai T, Hata J, Shintaku Y, Ohta H, Sogabe K, Mori S, Miyabe-Nishiwaki T, Okano HJ, Hamada Y, Hirabayashi T, Minamimoto T, Sadato N, Okano H, Oishi K.
Neuroimage. 2023 Apr 7:120096. doi: 10.1016/j.neuroimage.2023.120096. Online ahead of print.
PMID: 37031828 プレスリリース

Neuroprotective effects of genome-edited human iPS cell-derived neural stem/progenitor cells on traumatic brain injury.
Imai R, Tamura R, Yo M, Sato M, Fukumura M, Takahara K, Kase Y, Okano H, Toda M.
Stem Cells. 2023 Apr 8:sxad028. doi: 10.1093/stmcls/sxad028. Online ahead of print.
PMID: 37029780 プレスリリース

A human induced pluripotent stem cell model from a patient with hereditary cerebral small vessel disease carrying a heterozygous R302Q mutation in HTRA1.
Qian E, Uemura M, Kobayashi H, Nakamura S, Ozawa F, Yoshimatsu S, Ishikawa M, Onodera O, Morimoto S, Okano H.
Inflamm Regen. 2023 Apr 3;43(1):23. doi: 10.1186/s41232-023-00273-7.
PMID: 37009886

Modeling the marmoset brain using embryonic stem cell-derived cerebral assembloids.
Kodera T, Takeuchi RF, Takahashi S, Suzuki K, Kassai H, Aiba A, Shiozawa S, Okano H, Osakada F.
Biochem Biophys Res Commun. 2023 May 21;657:119-127. doi: 10.1016/j.bbrc.2023.03.019. Epub 2023 Mar 11.
PMID: 37002985

Current status and prospects of regenerative medicine for spinal cord injury using human induced pluripotent stem cells: a review.
Inoue M, Yamaguchi R, He CCJ, Ikeda A, Okano H, Kohyama J.
Stem Cell Investig. 2023 Mar 10;10:6. doi: 10.21037/sci-2022-037. eCollection 2023.
PMID: 36970397

The original strain of SARS-CoV-2, the Delta variant, and the Omicron variant infect microglia efficiently, in contrast to their inability to infect neurons: Analysis using 2D and 3D cultures.
Kase Y, Sonn I, Goto M, Murakami R, Sato T, Okano H.
Exp Neurol. 2023 Mar 11;363:114379. doi: 10.1016/j.expneurol.2023.114379. Online ahead of print.
PMID: 36914084

Clinical, histopathological and molecular risk factors for recurrence of pilocytic astrocytomas: brainstem/spinal location, nestin expression and gain of 7q and 19 are associated with early tumor recurrence.
Tamura R, Iwanami A, Ohara K, Nishimoto M, Pareira ES, Miwa T, Tsuzaki N, Kuranari Y, Morimoto Y, Toda M, Okano H, Nakamura M, Yoshida K, Sasaki H.
Brain Tumor Pathol. 2023 Mar 9. doi: 10.1007/s10014-023-00453-w. Online ahead of print.
PMID: 36892668
Influence of Diffusion Time and Temperature on Restricted Diffusion Signal: A Phantom Study.
Oshiro H, Hata J, Nakashima D, Hayashi N, Haga Y, Hagiya K, Yoshimaru D, Okano H.
Magn Reson Med Sci. 2023 Feb 8. doi: 10.2463/mrms.mp.2022-0103. Online ahead of print.
PMID: 36754420

Epigenetic profile of Japanese supercentenarians: a cross-sectional study.
Komaki S, Nagata M, Arai E, Otomo R, Ono K, Abe Y, Ohmomo H, Umekage S, Shinozaki NO, Hachiya T, Sutoh Y, Otsuka-Yamasaki Y, Arai Y, Hirose N, Yoneyama A, Okano H, Sasaki M, Kanai Y, Shimizu A.
Lancet Healthy Longev. 2023 Feb;4(2):e83-e90. doi: 10.1016/S2666-7568(23)00002-8.
PMID: 36738748

Microenvironmental modulation in tandem with human stem cell transplantation enhances functional recovery after chronic complete spinal cord injury.
Hashimoto S, Nagoshi N, Shinozaki M, Nakanishi K, Suematsu Y, Shibata T, Kawai M, Kitagawa T, Ago K, Kamata Y, Yasutake K, Koya I, Ando Y, Minoda A, Shindo T, Shibata S, Matsumoto M, Nakamura M, Okano H.
Biomaterials. 2023 Apr;295:122002. doi: 10.1016/j.biomaterials.2023.122002. Epub 2023 Jan 26.
PMID: 36736008 プレスリリース

Rehabilitative Training Enhances Therapeutic Effect of Human-iPSC-Derived Neural Stem/Progenitor Cells Transplantation in Chronic Spinal Cord Injury.
Shibata T, Tashiro S, Shibata S, Shinozaki M, Shindo T, Hashimoto S, Kawai M, Kitagawa T, Ago K, Matsumoto M, Nakamura M, Okano H, Nagoshi N.
Stem Cells Transl Med. 2023 Mar 3;12(2):83-96. doi: 10.1093/stcltm/szac089.
PMID: 36647673 プレスリリース

Generation of two induced pluripotent stem cell lines from individuals without auditory disorders.
Okura S, Ishii H, Suzuki A, Saegusa C, Fujiki K, Sugano K, Suzuki N, Saeki T, Matsuzaki S, Ozawa H, Fujioka M, Hosoya M, Okano H.
Stem Cell Res. 2023 Mar;67:103017. doi: 10.1016/j.scr.2023.103017. Epub 2023 Jan 4.
PMID: 36630839