heart Heart Data

Research TitleThe gene expression signature of myocardial tissue from the patients with dilated cardiomyopathy.
InvestigatorMasatsugu Ohtsuki (Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine)
SummaryThere is an emerging hypothesis that dilated cardiomyopathy (DCM) is a manifestation of end-stage heart failure (ESHF) resulting from a gfinal common pathwayh despite a heterogeneity of primary etiologies. We performed genome-wide expression profiling, by means of high-density oligonucleotide microarrays, of myocardial tissue from patients with DCM or specific cardiomyopathy, as well as autopsy samples from non-cardiac death as a control. Unsupervised clustering of the profiles indicated that samples with DCM and other specific cardiomyopathies were scrambled, but constituted a single cluster representing ESHF. Differentially expressed genes between ESHF and non-disease samples should include both genes reactive to heart failure (HF) and those responsible for ESHF. With the aid of samples with acute HF without DCM and those with DCM without HF, we successfully distinguished ESHF genes from HF genes. Our findings suggest that the transcriptional signature of myocardial tissue can be potentially utilized as a diagnostic or prognostic tool for cases of severe HF.
OrganismHomo sapiens
Data Description

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Experimental Design
GEO Series Accession No.GSE9800



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