研究業績

論文（2007–）

  1. H.H. Chua, T. Kameyama, A. Mayeda & T.H. Yeh (2019). Cancer-specifically re-spliced TSG101 mRNA promotes invasion and matastasis of nasopharyngeal carcinoma. Int. J. Mol. Sci., 20, 773.
  2. R. Yoshimoto, K. Rahimi, T. Hansen, J. Kjems & A. Mayeda (2018). The functional circular RNA, ciRS-7 (CDR1as), is biosynthesized using back-splicing promoted by inverted mammalian-wide MIRs but not primate-specifici. Alus. bioRxiv., 411231; doi: https://doi.org/10.1101/411231.
  3. K. Ohe*, S. Miyajima, I. Abe, T. Tanaka, Y. Hamaguchi, Y. Harada, Y. Horita, Y. Beppu, F. Ito, T. Yamasaki, H. Terai, M. Mori, Y. Murata, M. Tanabe, K. Ashida, K. Kobayashi, M. Enjoji, T. Yanase, N. Harada, T. Utsumi & A. Mayeda (2018). HMGA1a induces alternative splicing of estrogen receptor alpha in MCF-7 human breast cancer cells. J. Steroid Biochem. Mol. Biol., 182, 21–26. (*Corresponding author)
  4. K. Ohe*, S. Miyajima, T. Tanaka, Y. Hamaguchi, Y. Harada, Y. Horita, Y. Beppu, F. Ito, T. Yamasaki, H. Terai, M. Mori, Y. Murata, M. Tanabe, I. Abe, K. Ashida, K. Kobayashi, M. Enjoji, T. Nomiyama, T. Yanase, N. Harada, T. Utsumi & A. Mayeda* (2018). HMGA1a induces alternative splicing of the Estrogen Receptor-α gene by trapping U1 snRNP to an upstream pseudo-5’ splice site. Front. Mol. Biosci., 5, 52. (*Corresponding authors)
  5. A. Abe, Y. Yamamoto, A. Katsumi, A. Okamoto, M. Tokuda, Y. Inaguma, K. Yamamoto, M. Yanada, T. Kanie, A. Tomita, Y. Akatsuka, M. Okamoto, T. Kameyama, A. Mayeda & N. Emi (2018). Rearrangement of VPS13B, a causative gene of Cohen syndrome, in a case of RUNX1-RUNX1T1 luekemia with t(8;12;21). Int. J. Hematol., in press.
  6. K. Fukumura, K. Inoue & A. Mayeda (2018). Splicing activator RNPS1 suppresses errors in pre-mRNA splicing: A key factor for mRNA quality control. Biochem. Biophys. Res. Commun., 496, 921–926.
  7. R. Yoshimoto, D. Kaida, M. Furuno, AM, Burroughts, S. Noma, H. Suzuki, Y. Kawamura, Y. Hayashizaki, A. Mayeda & M. Yoshida (2017). Global analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A. RNA, 23, 47–57.
  8. 福村 和宏, 前田 明 (2016). mRNA前駆体スプライシングの精度を保つ未知の機構を探る. 実験医学, 34, 3116–3121.
  9. 片岡 直行, 前田 明 (2016). mRNA前駆体スプライシング： 分子機構とその破綻による疾患まで. 実験医学, 34, 3108–3115.
  10. 芳本 玲, 前田 明 (2016). 環状RNA（circRNA）. DOJIN BIOSCIENCEシリーズ： ノンコーディングRNA―RNA分子の全体像を俯瞰する．化学同人．京都．, 271–279.
  11. R. Yoshimoto, A. Mayeda, M. Yoshida & S. Nakagawa (2016). MALAT1 long non-coding RNA in cancer. Biochem. Biophys. Acta, 1859, 192–199.
  12. H. Suzuki, Y. Aoki, T. Kameyama, T. Saito, S. Masuda, J. Tanihata, T. Nagata, A. Mayeda, S. Takeda & T. Tsukahara (2016). Endogenous multiple exon skipping and back-splicing at the DMD mutation hotspot. Int. J. Mol. Sci., 17, E1722.
  13. K. Fukumura, S. Wakabayashi, N. Kataoka, H. Sakamoto, Y. Suzuki, K. Nakai, A. Mayeda & K. Inoue (2016). The exon junction complex controls the efficient and faithful splicing of a subset of transcripts involved in mitotic cell-cycle progression. Int. J. Mol. Sci., 17, E1153.
  14. A. Abe, S. Mizuta, A. Okamoto, Y. Yamamoto, T. Kameyama, A. Mayeda & N. Emi (2016). Transcriptional activation of platelet-derived growth factor receptor α and GS homeobox 2 resulting from E26 transformation-specific variant 6 translocation in a case of acute myeloid leukemia with t(4;12)(q12;p13). Int. J. Lab. Hematol., 38, e15–18.
  15. A. Abe, Y. Yamamoto, S. Iba, T. Kanie, A. Okamoto, M. Tokuda, Y. Inaguma, M. Yanada, S Morishima, S. Mizuta, Y. Akatsuka, M. Okamoto, T. Kameyama, A. Mayeda & N. Emi (2016). ETV6-LPXN fusion transcript generated by t(11;12)(q12.1;p13) in a patient with relapsing acute myeloid leukemia with NUP98-HOXA9. Genes Chromosomes Cancer, 55, 242–250.
  16. 前田 明 (2015). 生命現象を支える多種多様の蛋白質が正しく作られる仕組：遺伝子に隠されたスプライシング調節暗号を解く．DNA多型, 23, 3–8.
  17. 亀山 俊樹, 前田 明 (2015). がん細胞で異常なタンパク質が作られる仕組みを「mRNA再スプライシング」現象から探る．ファルマシア, 51, 22–26.
  18. A. Abe, Y. Yamamoto, S. Iba, A. Okamoto, M. Tokuda, Y. Inaguma, M. Yanada, S Morishima, T. Kanie, M. Tsuzuki, Y. Akatsuka, S. Mizuta, M. Okamoto, T. Kameyama, A. Mayeda & N. Emi (2015). NUP214-RAC1 and RAC1-COL12A1 fusion in complex variant translocations involving chromosomes 6, 7, and 9 in an AML case with DEK-NUP214. Cytogenet. Genome Res., 146, 279–284.
  19. M.K. Shimada, N. Sasaki-Haraguch & A. Mayeda (2015). Identification and validation of evolutionarily conserved unusually short pre-mRNA introns in the human genome. Int. J. Mol. Sci., 16, 10376–10388.
  20. Matsushita, F., Kameyama, T., Kadokawa, Y. and Marunouchi, T. (2014) Spatio-temporal expression pattern of Myt/NZF family zinc finger transcription factors during mouse nervous system development. Dev. Dyn., 243, 588-600.
  21. Rahman, M.A., Masuda, A., Ohe, K., Ito, M., Hutchinson, D.O., Mayeda, A., Engel, A.G. and Ohno, K. (2013) HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing supression of CHRNA1pre-mRNA. Sci. Rep., 3, 2931.
  22. Suzuki, H., Kameyama, T., Ohe, K., Tsukahara, T. and Mayeda, A. (2013) Nested introns in an intron: evidence of multi-stepp splicing of a large intron in the human dystrophin pre-mRNA. FEBS Lett., 587, 555-561.
  23. Kameyama, T., Suzuki, H. and Mayeda, A. (2012) Re-splicing of mature mRNA in cancer cells promotes activation of distant weak alternative splice sites. Nucleic Acids Res., 40, 7896-7906.
  24. Sasaki-Haraguchi, N., Shimada, M.K., Taniguchi, I., Ohno, M. and Mayeda, A. (2012) Mechanistic insights into human pre-mRNA splicing of human ultra-short introns: Potential unusual mechanism identifies G-rich introns. Biochem. Biophys. Res. Commun., 423, 289–294.
  25. Miyagawa, R., Tano, K., Mizuno, R., Nakamura, Y., Ijiri, K., Rakwal, R., Shibato, J., Masuo, Y., Mayeda, A., Hirose, T. et al. (2012) Identification of cis- and trans-acting factors involved in the localization of MALAT-1 noncoding RNA to nuclear speckles. RNA, 18, 738–751.
  26. Morikawa, T., Manabe, T., Ito, T., Yamada, S., Yoshimi, A., Ozaki, N. and Mayeda, A. (2010). Neurochem Int, 56, 736–739.
  27. Ohe, K. and Mayeda, A. (2010) HMGA1a trapping of U1 snRNP at an authentic 5' splice site induces aberrant exon skipping in sporadic Alzheimer's disease. Mol. Cell. Biol., 30, 2220–2228.
  28. Manabe, T., Ohe, K., Katayama, T., Matsuzaki, S., Yanagita, T., Okuda, H., Bando, Y., Imaizumi, K., Reeves, R., Tohyama, M. et al. (2007) HMGA1a: sequence-specific RNA-binding factor causing sporadic Alzheimer's disease-linked exon skipping of presenilin-2 pre-mRNA. Genes Cells, 12, 1179–1191.

2007年以前の代表的な論文

  1. Suzuki, H., Zuo, Y., Wang, J., Zhang, M.Q., Malhotra, A. and Mayeda, A. (2006) Characterization of RNase R-digested cellular RNA source that consists of lariat and circular RNAs from pre-mRNA splicing. Nucleic Acids Res., 34, e63.
  2. Trembley, J.H., Tatsumi, S., Sakashita, E., Loyer, P., Slaughter, C.A., Suzuki, H., Endo, H., Kidd, V.J. and Mayeda, A. (2005) Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation. Mol. Cell. Biol., 25, 1446–1457.
  3. Sakashita, E., Tatsumi, S., Werner, D., Endo, H. and Mayeda, A. (2004) Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo. Mol. Cell. Biol., 24, 1174–1187.
  4. Manabe, T., Katayama, T., Sato, N., Gomi, F., Hitomi, J., Yanagita, T., Kudo, T., Honda, A., Mori, Y., Matsuzaki, S. et al. (2003) Induced HMGA1a expression causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease. Cell Death Differ., 10, 698–708.
  5. Mayeda, A., Badolato, J., Kobayashi, R., Zhang, M.Q., Gardiner, E.M. and Krainer, A.R. (1999) Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing. EMBO J., 18, 4560–4570.
  6. Mayeda, A., Munroe, S.H., Caceres, J.F. and Krainer, A.R. (1994) Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. EMBO J., 13, 5483–5495.
  7. Mayeda, A. and Krainer, A.R. (1992) Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell, 68, 365–375.
  8. Krainer, A.R., Mayeda, A., Kozak, D. and Binns, G. (1991) Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators. Cell, 66, 383–394.

日本語総説

  1. 亀山俊樹、前田明 (2015) がん細胞で異常なタンパク質が作られる仕組みを「mRNA再スプライシング」現象から探る. ファルマシア 51, 22–26.
  2. 眞部孝幸、前田明 (2011) スプライシング異常から解析する統合失調症. 臨床検査 55, 893–899.
  3. 亀山俊樹、前田明 (2010) 癌の発生と進行に関わるmRNA前駆体スプライシングの破綻. 実験医学 28, 1597–1605.
  4. 前田明、眞部孝幸、大江賢治 (2009) がん遺伝子産物HMGA1aがひき起こす孤発性アルツハイマー病の異常スプライシング. 蛋白質核酸酵素 54, 2245-2250.
  5. 前田明、鈴木仁 (2003) mRNA前駆体スプライシング-多様化した遺伝子発現情報網の源. 蛋白質核酸酵素 48, 404-413.
  6. 前田明、大江賢治 (2003) RNAのプロセッシング. RNAがわかる: 多彩な生命現象を司るRNAの機能からRNAi、創薬への応用まで (中村義一/編).
  7. 前田明 (1998) mRNA前駆体のスプライシングに関わるスプライシング因子群. 細胞工学 17, 1526-1533.

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