感染症・血液・腫瘍・神経
感染症分野では主に、HHV-6、ロタウイルス、水痘ワクチンについての臨床ウイルス学的研究を行っています。またHHV-6、ロタウイルスに関しては、各種検査も受け付けています。検査依頼のページをご覧ください。
HHV-6やヘルペスウイルス全般、およびロタウイルスの臨床、研究にご興味のある方の国内留学や共同研究についても積極的に取り組んでゆきたいと考えています。御相談下さい。
血液分野は、名古屋大学小児科に事務局のある小児再生不良貧血治療研究会のメンバーとして、臍帯血移植や2回目移植を担当して解析を進め、小児再生不良性貧血の臨床研究について取り組んでおります。また、日本小児がん研究グループ(JCCG)のHLH/LCH委員会委員として、血球貪食性リンパ組織球症(HLH)及びランゲルハンス細胞組織球症(LCH)といった希少疾患の病態解明や治療についての相談を受けております。
小児神経分野では患者さんの診療を軸とした臨床研究を行っています。扱う疾患は幅広く、てんかん、急性脳症、脳性麻痺、先天性脳奇形、新生児脳障害などの小児中枢神経疾患や、Guillain-Barre症候群、重症筋無力症、筋ジストロフィー、神経変性疾患、神経皮膚症候群など、多岐に渡ります。感染症分野や血液・腫瘍分野と共同して、下記の研究に取り組んでいます。
HHV-6やヘルペスウイルス全般、およびロタウイルスの臨床、研究にご興味のある方の国内留学や共同研究についても積極的に取り組んでゆきたいと考えています。御相談下さい。
血液分野は、名古屋大学小児科に事務局のある小児再生不良貧血治療研究会のメンバーとして、臍帯血移植や2回目移植を担当して解析を進め、小児再生不良性貧血の臨床研究について取り組んでおります。また、日本小児がん研究グループ(JCCG)のHLH/LCH委員会委員として、血球貪食性リンパ組織球症(HLH)及びランゲルハンス細胞組織球症(LCH)といった希少疾患の病態解明や治療についての相談を受けております。
小児神経分野では患者さんの診療を軸とした臨床研究を行っています。扱う疾患は幅広く、てんかん、急性脳症、脳性麻痺、先天性脳奇形、新生児脳障害などの小児中枢神経疾患や、Guillain-Barre症候群、重症筋無力症、筋ジストロフィー、神経変性疾患、神経皮膚症候群など、多岐に渡ります。感染症分野や血液・腫瘍分野と共同して、下記の研究に取り組んでいます。
スタッフ
- 吉川哲史（教授）
- 川田潤一（教授）
- 石原尚子（准教授）
- 河村吉紀（岡崎医療センター 准教授）
- 田中真己人（講師）
- 三浦浩樹（講師）
- 三宅未紗（ばんたね病院 助教）
- 小澤慶（助教）
- 古川源（助教）
- 吉兼綾美（助教）
業績（過去3年間 英文）
Oral Valganciclovir Therapy in Infants Aged ≤2 Months with Congenital Cytomegalovirus Disease: A Multicenter, Single-Arm, Open-Label Clinical Trial in Japan. Morioka I, Kakei Y, Omori T, Nozu K, Fujioka K, Takahashi N, Yoshikawa T, Moriuchi H, Ito Y, Oka A; Japanese Congenital Cytomegalovirus Study Group. J Clin Med. 2022 Jun 21;11(13):3582. doi: 10.3390/jcm11133582.
Unremarkable antibody responses against various infectious agents after inoculation with the BNT162b2 COVID-19 vaccine. Kozawa K, Miura H, Kawamura Y, Higashimoto Y, Ihira M, Yoshikawa T. J Med Virol. 2022 Oct;94(10):4583-4585. doi: 10.1002/jmv.27895. Epub 2022 Jun 9.
Correlation between anti-S IgG and neutralizing antibody titers against three live SARS-CoV-2 variants in BNT162b2 vaccine recipients. Higashimoto Y, Kozawa K, Miura H, Kawamura Y, Ihira M, Hiramatsu H, Suzuki R, Haga K, Takai-Todaka R, Sawada A, Katayama K, Yoshikawa T. Hum Vaccin Immunother. 2022 Nov 30;18(6):2105611. doi: 10.1080/21645515.2022.2105611. Epub 2022 Sep 12.
Anti-N-methyl-D-aspartate receptor encephalitis with concurrent human herpes virus-6A deoxyribonucleic acid detection: An autopsy case. Shimohama S, Iizuka T, Takizawa T, Watanabe N, Tezuka T, Matsuda K, Yamanoi K, Kanazawa N, Kawamura Y, Yoshikawa T, Suzuki T, Takao M, Nakahara J, Izawa Y. Neuropathology. 2022 Nov 8. doi: 10.1111/neup.12881.
Rotavirus genotypes and clinical outcome of natural infection based on vaccination status in the post-vaccine era. Kozawa K, Higashimoto Y, Kawamura Y, Miura H, Negishi T, Hattori F, Ihira M, Komoto S, Taniguchi K, Yoshikawa T. Hum Vaccin Immunother. 2022 Dec 31;18(1):2037983. doi: 10.1080/21645515.2022.2037983. Epub 2022 Mar 3.
Human herpesvirus 6 DNA was not detected in a brain specimen from a patient with mesial temporal sclerosis after status epilepticus due to human herpesvirus 6 infection. Kawamura Y, Maesawa S, Numoto S, Saito R, Yoshikawa T, Okumura A. Epilepsia Open. 2022 Dec;7(4):817-821. doi: 10.1002/epi4.12634. Epub 2022 Aug 23.
Systemic herpes simplex virus infection in a child with eczema herpeticum. Akamatsu M, Kawamura Y, Miura H, Sugimoto E, Okamoto K, Nakajima Y, Kozawa K, Furukawa G, Tanaka M, Kudo K, Yoshikawa T. Pediatr Dermatol. 2023 May-Jun;40(3):582-583. doi: 10.1111/pde.15253. Epub 2023 Jan 22.
Usefulness of three-dimensional computed tomography venography differentiating calvarium subperiosteal hematoma crossing the suture lines due to hair pulling from subgaleal hematoma: case report and review of the literature.
Matsumura K, Muto J, Tanaka M, Joko M, Yoshikawa T, Hirose Y.
Childs Nerv Syst. 2022 Oct;38(10):2017-2020. doi: 10.1007/s00381-022-05517-4. Epub 2022 Apr 5.
TREC/KREC Newborn Screening followed by Next-Generation Sequencing for Severe Combined Immunodeficiency in Japan.
Wakamatsu M, Kojima D, Muramatsu H, Okuno Y, Kataoka S, Nakamura F, Sakai Y, Tsuge I, Ito T, Ueda K, Saito A, Morihana E, Ito Y, Ohashi N, Tanaka M, Tanaka T, Kojima S, Nakajima Y, Ito T, Takahashi Y.
J Clin Immunol. 2022 Nov;42(8):1696-1707. doi: 10.1007/s10875-022-01335-0. Epub 2022 Jul 28.
Whole-exome analysis of 177 pediatric patients with undiagnosed diseases. Narita K, Muramatsu H, Narumi S, Nakamura Y, Okuno Y, Suzuki K, Hamada M, Yamaguchi N, Suzuki A, Nishio Y, Shiraki A, Yamamori A, Tsumura Y, Sawamura F, Kawaguchi M, Wakamatsu M, Kataoka S, Kato K, Asada H, Kubota T, Muramatsu Y, Kidokoro H, Natsume J, Mizuno S, Nakata T, Inagaki H, Ishihara N, Yonekawa T, Okumura A, Ogi T, Kojima S, Kaname T, Hasegawa T, Saitoh S, Takahashi Y. Sci Rep. 2022 Aug 26;12(1):14589. doi: 10.1038/s41598-022-14161-6.
A case of 46,XY disorders of sex development with congenital heart disease caused by a GATA4 variant. Shichiri Y, Kato Y, Inagaki H, Kato T, Ishihara N, Miyata M, Boda H, Kojima A, Miyake M, Kurahashi H. Congenit Anom (Kyoto). 2022 Sep;62(5):203-207. doi: 10.1111/cga.12482. Epub 2022 Jul 6
Early immunological responses to the mRNA SARS-CoV-2 vaccine in patients with neuromuscular disorders. Iwayama H, Ishihara N, Kawahara K, Madokoro Y, Togawa Y, Muramatsu K, Murakami A, Kuru S, Kumagai T, Ohashi W, Nanya K, Hasegawa S, Katsuno M, Okumura A. Front Immunol. 2022 Sep 29;13:996134. doi: 10.3389/fimmu.2022.996134. eCollection 2022.
Pathological gait in Rett syndrome: Quantitative evaluation using three-dimensional gait analysis. Suzuki T, Ito Y, Ito T, Kidokoro H, Noritake K, Tsujimura K, Saitoh S, Yamamoto H, Ochi N, Ishihara N, Yasui I, Sugiura H, Nakata T, Natsume J. Eur J Paediatr Neurol. 2023 Jan;42:15-21. doi: 10.1016/j.ejpn.2022.11.010. Epub 2022 Dec 5.
Dynamics of salivary human herpesvirus-6 and -7 shedding in pregnant women. Suzuki N, Ihira M, Enya Y, Takahashi Y, Izuru C, Igarashi R, Higashimoto Y, Miura H, Takanashi A, Fujimoto K, Kawamura Y, Yoshikawa T. J Med Virol. 2022 Mar 4. doi: 10.1002/jmv.27692.
An atypical case of Kawasaki disease with severe pneumonia in a neonate. Kawamura Y, Miura H, Saito K, Kanno T, Yokoyama T, Aizawa Y, Yoshikawa T. BMC Pediatr. 2022 Mar 14;22(1):132. doi: 10.1186/s12887-022-03203-7.
Nosocomial infection with rotavirus vaccine strain in paediatric patients with immunodeficiency. Miura H, Taniguchi K, Narita K, Kawamura Y, Kozawa K, Muramatsu H, Takahashi Y, Ihira M, Yoshikawa T. J Hosp Infect. 2022 Mar;121:9-13. doi: 10.1016/j.jhin.2021.12.009. Epub 2021 Dec 14.
Case Report: Rotavirus Vaccination and Severe Combined Immunodeficiency in Japan. Tanita K, Kawamura Y, Miura H, Mitsuiki N, Tomoda T, Inoue K, Iguchi A, Yamada M, Yoshida T, Muramatsu H, Tada N, Matsui T, Kato M, Eguchi K, Ishimura M, Ohga S, Imai K, Morio T, Yoshikawa T, Kanegane H. Front Immunol. 2022 Feb 23;13:786375. doi: 10.3389/fimmu.2022.786375. eCollection 2022. PMID: 35281013
Peripheral venous catheter-related candidemia in an immunocompetent child. Sudo Y, Kawamura Y, Miura H, Yokoi K, Yoshikawa T. Pediatr Int. 2022 Jan;64(1):e14883. doi: 10.1111/ped.14883. Epub 2021 Nov 30.
Detection of human herpesviruses in cerebrospinal fluids of patients suspected of central nervous system infection. Ishimaru S, Kawamura Y, Miura H, Shima S, Ueda A, Mutoh T, Yoshikawa T. J Neurovirol. 2021 Dec 30. doi: 10.1007/s13365-021-01040-5.
Meningitis Caused by the Live Varicella Vaccine Virus: Metagenomic Next Generation Sequencing, Immunology Exome Sequencing and Cytokine Multiplex Profiling. Ramachandran PS, Wilson MR, Catho G, Blanchard-Rohner G, Schiess N, Cohrs RJ, Boutolleau D, Burrel S, Yoshikawa T, Wapniarski A, Heusel EH, Carpenter JE, Jackson W, Ford BA, Grose C. Viruses. 2021 Nov 16;13(11):2286. doi: 10.3390/v13112286.
Epstein-Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV. Venturini C, Houldcroft C, Lazareva A, Wegner F, Morfopoulou S, Amrolia P, Golwala Z, Rao A, Marks S, Simmonds J, Yoshikawa T, Farrell P, Cohen J, Worth A, Breuer J. Brit J Haematol 2021 Oct;195(2):249-255. doi: 10.1111/bjh.17790.
A case of aseptic meningitis without skin rash caused by Oka Varicella Vaccine. Kawamura Y, Suzuki D, Kono T, Miura H, Kozawa K, Mizuno H, Yoshikawa T. Pediatr Infect Dis J. 2021 Aug 24. doi: 10.1097/INF.0000000000003316.
Full genome-based characterization of G4P[6] rotavirus strains from diarrheic patients in Thailand: Evidence for independent porcine-to-human interspecies transmission events. Tacharoenmuang R, Guntapong R, Upachai S, Singchai P, Fukuda S, Ide T, Hatazawa R, Sutthiwarakom K, Kongjorn S, Onvimala N, Luechakham T, Ruchusatsawast K, Kawamura Y, Sriwanthana B, Motomura K, Tatsumi M, Takeda N, Yoshikawa T, Murata T, Uppapong B, Taniguchi K, Komoto S. Virus Genes. 2021 Aug;57(4):338-357. doi: 10.1007/s11262-021-01851-y. Epub 2021 Jun 9.
Effect of Lactococcus lactis Strain Plasma on HHV-6 and HHV-7 Shedding in Saliva: A Prospective Observational Study. Miura H, Ihira M, Kozawa K, Kawamura Y, Higashimoto Y, Hattori F, Yoshikawa T. Microorganisms. 2021 Aug 8;9(8):1683. doi: 10.3390/microorganisms9081683.
Implementing vaccination policies based upon scientific evidence in Japan. Yoshikawa T. Vaccine. 2021 Aug 7:S0264-410X(21)00968-3.
Evaluation of varicella vaccine effectiveness during outbreaks in schools or nurseries by cross-sectional study. Kawamura Y, Hattori F, Higashimoto Y, Kozawa K, Yoshikawa T. Vaccine. 2021 May 18;39(21):2901-2905. doi: 10.1016/j.vaccine.2021.04.009. Epub 2021 Apr 22.
Inherited Chromosomally Integrated Human Herpesvirus 6 Is a Risk Factor for Spontaneous Abortion. Miura H, Kawamura Y, Ohye T, Hattori F, Kozawa K, Ihira M, Yatsuya H, Nishizawa H, Kurahashi H, Yoshikawa T. J Infect Dis. 2021 May 28;223(10):1717-1723. doi: 10.1093/infdis/jiaa606.
Involvement of brain structures in childhood epilepsy with centrotemporal spikes. Ito Y, Maki Y, Okai Y, Kidokoro H, Bagarinao E, Takeuchi T, Ohno A, Nakata T, Ishihara N, Okumura A, Yamamoto H, Maesawa S, Natsume J. Pediatr Int. 2022 Jan;64(1):e15001. doi: 10.1111/ped.15001.
Itpr1 regulates the formation of anterior eye segment tissues derived from neural crest cells. Kinoshita A, Ohyama K, Tanimura S, Matsuda K, Kishino T, Negishi Y, Asahina N, Shiraishi H, Hosoki K, Tomiwa K, Ishihara N, Mishima H, Mori R, Nakashima M, Saitoh S, Yoshiura KI. Development. 2021 Aug 15;148(16):dev188755. doi: 10.1242/dev.188755. Epub 2021 Aug 26.
Establishment of in-hospital clinical network for patients with neurofibromatosis type 1 in Nagoya University Hospital. Nishida Y, Ikuta K, Natsume A, Ishihara N, Morikawa M, Kidokoro H, Muramatsu Y, Nonobe N, Ishizuka K, Takeichi T, Kanbe M, Mizuno S, Imagama S, Ozaki N. Sci Rep. 2021 Jun 7;11(1):11933. doi: 10.1038/s41598-021-91345-6.
Hippocampal Atrophy in Pediatric Transplant Recipients with Human Herpesvirus 6B. Miyake M, Kawamura Y, Ishihara N, Suzuki S, Miura H, Sakaguchi Y, Tanaka M, Takahashi Y, Kojima S, Toyama H, Natsume J, Yoshikawa T. Microorganisms. 2021 Apr 8;9(4):776. doi: 10.3390/microorganisms9040776.
Salvage therapy with 2-chlorodeoxyadenosine for refractory and relapsed pediatric Langerhans cell histiocytosis: an updated nationwide survey in Japan. Taniguchi M, Sakamoto K, Shioda Y, Doi T, Kudo K, Fujino H, Kudo K, Morimoto A. Int J Hematol. 2021 Mar;113(3):461-463.
Coinfection With Human Herpesvirus (HHV)-6B in Immunocompetent, Healthy Individuals With Chromosomally Integrated HHV-6A. Miura H, Ohye T, Kozawa K, Hattori F, Kawamura Y, Ihira M, Kurahashi H, Yoshikawa T. J Pediatric Infect Dis Soc. 2021 Mar 26;10(2):175-178. doi: 10.1093/jpids/piaa009.
Immune response against SARS-CoV-2 in pediatric patients including young infants. Kawamura Y, Higashimoto Y, Miura H, Ihira M, Inaba M, Ito R, Kozawa K, Yoshikawa T. J Med Virol. 2021 Mar;93(3):1776-1779. doi: 10.1002/jmv.26493. Epub 2020 Sep 29.
Inherited chromosomally integrated human herpesvirus 6 and autoimmune connective tissue diseases. Kawamura Y, Hashimoto T, Miura H, Kozawa K, Yoshikawa A, Ikeda N, Yatsuya H, Yasuoka H, Yoshikawa T. J Clin Virol. 2020 Nov;132:104656. doi: 10.1016/j.jcv.2020.104656. Epub 2020 Oct 5.
Trend in varicella patients 4 years after implementation of universal two-dose varicella vaccination in Japan. Hattori F, Kozawa K, Miura H, Kawamura Y, Higashimoto Y, Yoshikawa A, Ihira M, Yoshikawa T; Nagoya VZV Study Group. Vaccine. 2020 Oct 27;38(46):7331-7336.
Molecular characterization of rotaviruses obtained from patients with rotavirus-associated encephalitis/encephalopathy. Ihira M, Kawamura Y, Miura H, Hattori F, Higashimoto Y, Sugata K, Ide T, Komoto S, Taniguchi K, Yoshikawa T. Microbiol Immunol. 2020 Aug;64(8):541-555. doi: 10.1111/1348-0421.12827. Epub 2020 Aug 4.
Three Adolescents With Primary Human Herpesvirus 7 Infection During a Measles Outbreak. Kono T, Hattori F, Kawamura Y, Miura H, Sudo Y, Suzuki M, Yoshikawa T. Pediatr Infect Dis J. 2020 Aug;39(8):e209-e211.
Clinical Features of Complex Febrile Seizure Caused by Primary Human Herpesvirus 6B Infection. Miyake M, Kawamura Y, Hattori F, Miura H, Ishihara N, Yoshikawa T. Pediatr Neurol. 2020 Aug;109:52-55. doi: 10.1016/j.pediatrneurol.2020.03.015. Epub 2020 Mar 28.
Frequency of subclinical herpes zoster in pediatric hematology-oncology patients receiving chemotherapy: A retrospective cohort analysis. Kozawa K, Miura H, Kawamura Y, Tanaka M, Kudo K, Higashimoto Y, Ihira M, Yoshikawa T. J Med Virol. 2020 Aug;92(8):1260-1265.
Rapid generation of rotavirus single-gene reassortants by means of eleven plasmid-only based reverse genetics. Fukuda S, Hatazawa R, Kawamura Y, Yoshikawa T, Murata T, Taniguchi K, Komoto S. J Gen Virol. 2020 Aug;101(8):806-815.
Endogenization and excision of human herpesvirus 6 in human genomes. Liu X, Kosugi S, Koide R, Kawamura Y, Ito J, Miura H, Matoba N, Matsuzaki M, Fujita M, Kamada AJ, Nakagawa H, Tamiya G, Matsuda K, Murakami Y, Kubo M, Aswad A, Sato K, Momozawa Y, Ohashi J, Terao C, Yoshikawa T, Parrish NF, Kamatani Y. PLoS Genet. 2020 Aug 10;16(8):e1008915. doi: 10.1371/journal.pgen.1008915. eCollection 2020 Aug.
Full genome characterization of novel DS-1-like G9P[8] rotavirus strains that have emerged in Thailand. Fukuda S, Tacharoenmuang R, Guntapong R, Upachai S, Singchai P, Ide T, Hatazawa R, Sutthiwarakom K, Kongjorn S, Onvimala N, Ruchusatsawast K, Rungnopakun P, Mekmallika J, Kawamura Y, Motomura K, Tatsumi M, Takeda N, Murata T, Yoshikawa T, Uppapong B, Taniguchi K, Komoto S. PLoS One. 2020 Apr 22;15(4):e0231099
Human herpesvirus-6B infection in pediatric allogenic hematopoietic stem cell transplant patients: Risk factors and encephalitis. Miura H, Kawamura Y, Hattori F, Tanaka M, Kudo K, Ihira M, Yatsuya H, Takahashi Y, Kojima S, Sakaguchi H, Yoshida N, Hama A, Yoshikawa T. Transpl Infect Dis. 2020 Feb;22(1):e13203.
Nationwide retrospective review of hematopoietic stem cell transplantation in children with refractory Langerhans cell histiocytosis. Kudo K, Maeda M, Suzuki N, Kanegae H, Ohga S, Ishii E, Shioda Y, Imamura T, Imashuku S, Tsunematsu Y, Endo M, Shimada A, Koga Y, Hashii Y, Noguchi M, Unoue M, Tabuchi K, Morimoto A, on behalf of The Histiocytosis study group of the Japanese Society of Pediatric Hematology/Oncology. International Journal of Hematology (2020) 111:137–148.
Unremarkable antibody responses against various infectious agents after inoculation with the BNT162b2 COVID-19 vaccine. Kozawa K, Miura H, Kawamura Y, Higashimoto Y, Ihira M, Yoshikawa T. J Med Virol. 2022 Oct;94(10):4583-4585. doi: 10.1002/jmv.27895. Epub 2022 Jun 9.
Correlation between anti-S IgG and neutralizing antibody titers against three live SARS-CoV-2 variants in BNT162b2 vaccine recipients. Higashimoto Y, Kozawa K, Miura H, Kawamura Y, Ihira M, Hiramatsu H, Suzuki R, Haga K, Takai-Todaka R, Sawada A, Katayama K, Yoshikawa T. Hum Vaccin Immunother. 2022 Nov 30;18(6):2105611. doi: 10.1080/21645515.2022.2105611. Epub 2022 Sep 12.
Anti-N-methyl-D-aspartate receptor encephalitis with concurrent human herpes virus-6A deoxyribonucleic acid detection: An autopsy case. Shimohama S, Iizuka T, Takizawa T, Watanabe N, Tezuka T, Matsuda K, Yamanoi K, Kanazawa N, Kawamura Y, Yoshikawa T, Suzuki T, Takao M, Nakahara J, Izawa Y. Neuropathology. 2022 Nov 8. doi: 10.1111/neup.12881.
Rotavirus genotypes and clinical outcome of natural infection based on vaccination status in the post-vaccine era. Kozawa K, Higashimoto Y, Kawamura Y, Miura H, Negishi T, Hattori F, Ihira M, Komoto S, Taniguchi K, Yoshikawa T. Hum Vaccin Immunother. 2022 Dec 31;18(1):2037983. doi: 10.1080/21645515.2022.2037983. Epub 2022 Mar 3.
Human herpesvirus 6 DNA was not detected in a brain specimen from a patient with mesial temporal sclerosis after status epilepticus due to human herpesvirus 6 infection. Kawamura Y, Maesawa S, Numoto S, Saito R, Yoshikawa T, Okumura A. Epilepsia Open. 2022 Dec;7(4):817-821. doi: 10.1002/epi4.12634. Epub 2022 Aug 23.
Systemic herpes simplex virus infection in a child with eczema herpeticum. Akamatsu M, Kawamura Y, Miura H, Sugimoto E, Okamoto K, Nakajima Y, Kozawa K, Furukawa G, Tanaka M, Kudo K, Yoshikawa T. Pediatr Dermatol. 2023 May-Jun;40(3):582-583. doi: 10.1111/pde.15253. Epub 2023 Jan 22.
Usefulness of three-dimensional computed tomography venography differentiating calvarium subperiosteal hematoma crossing the suture lines due to hair pulling from subgaleal hematoma: case report and review of the literature.
Matsumura K, Muto J, Tanaka M, Joko M, Yoshikawa T, Hirose Y.
Childs Nerv Syst. 2022 Oct;38(10):2017-2020. doi: 10.1007/s00381-022-05517-4. Epub 2022 Apr 5.
TREC/KREC Newborn Screening followed by Next-Generation Sequencing for Severe Combined Immunodeficiency in Japan.
Wakamatsu M, Kojima D, Muramatsu H, Okuno Y, Kataoka S, Nakamura F, Sakai Y, Tsuge I, Ito T, Ueda K, Saito A, Morihana E, Ito Y, Ohashi N, Tanaka M, Tanaka T, Kojima S, Nakajima Y, Ito T, Takahashi Y.
J Clin Immunol. 2022 Nov;42(8):1696-1707. doi: 10.1007/s10875-022-01335-0. Epub 2022 Jul 28.
Whole-exome analysis of 177 pediatric patients with undiagnosed diseases. Narita K, Muramatsu H, Narumi S, Nakamura Y, Okuno Y, Suzuki K, Hamada M, Yamaguchi N, Suzuki A, Nishio Y, Shiraki A, Yamamori A, Tsumura Y, Sawamura F, Kawaguchi M, Wakamatsu M, Kataoka S, Kato K, Asada H, Kubota T, Muramatsu Y, Kidokoro H, Natsume J, Mizuno S, Nakata T, Inagaki H, Ishihara N, Yonekawa T, Okumura A, Ogi T, Kojima S, Kaname T, Hasegawa T, Saitoh S, Takahashi Y. Sci Rep. 2022 Aug 26;12(1):14589. doi: 10.1038/s41598-022-14161-6.
A case of 46,XY disorders of sex development with congenital heart disease caused by a GATA4 variant. Shichiri Y, Kato Y, Inagaki H, Kato T, Ishihara N, Miyata M, Boda H, Kojima A, Miyake M, Kurahashi H. Congenit Anom (Kyoto). 2022 Sep;62(5):203-207. doi: 10.1111/cga.12482. Epub 2022 Jul 6
Early immunological responses to the mRNA SARS-CoV-2 vaccine in patients with neuromuscular disorders. Iwayama H, Ishihara N, Kawahara K, Madokoro Y, Togawa Y, Muramatsu K, Murakami A, Kuru S, Kumagai T, Ohashi W, Nanya K, Hasegawa S, Katsuno M, Okumura A. Front Immunol. 2022 Sep 29;13:996134. doi: 10.3389/fimmu.2022.996134. eCollection 2022.
Pathological gait in Rett syndrome: Quantitative evaluation using three-dimensional gait analysis. Suzuki T, Ito Y, Ito T, Kidokoro H, Noritake K, Tsujimura K, Saitoh S, Yamamoto H, Ochi N, Ishihara N, Yasui I, Sugiura H, Nakata T, Natsume J. Eur J Paediatr Neurol. 2023 Jan;42:15-21. doi: 10.1016/j.ejpn.2022.11.010. Epub 2022 Dec 5.
Dynamics of salivary human herpesvirus-6 and -7 shedding in pregnant women. Suzuki N, Ihira M, Enya Y, Takahashi Y, Izuru C, Igarashi R, Higashimoto Y, Miura H, Takanashi A, Fujimoto K, Kawamura Y, Yoshikawa T. J Med Virol. 2022 Mar 4. doi: 10.1002/jmv.27692.
An atypical case of Kawasaki disease with severe pneumonia in a neonate. Kawamura Y, Miura H, Saito K, Kanno T, Yokoyama T, Aizawa Y, Yoshikawa T. BMC Pediatr. 2022 Mar 14;22(1):132. doi: 10.1186/s12887-022-03203-7.
Nosocomial infection with rotavirus vaccine strain in paediatric patients with immunodeficiency. Miura H, Taniguchi K, Narita K, Kawamura Y, Kozawa K, Muramatsu H, Takahashi Y, Ihira M, Yoshikawa T. J Hosp Infect. 2022 Mar;121:9-13. doi: 10.1016/j.jhin.2021.12.009. Epub 2021 Dec 14.
Case Report: Rotavirus Vaccination and Severe Combined Immunodeficiency in Japan. Tanita K, Kawamura Y, Miura H, Mitsuiki N, Tomoda T, Inoue K, Iguchi A, Yamada M, Yoshida T, Muramatsu H, Tada N, Matsui T, Kato M, Eguchi K, Ishimura M, Ohga S, Imai K, Morio T, Yoshikawa T, Kanegane H. Front Immunol. 2022 Feb 23;13:786375. doi: 10.3389/fimmu.2022.786375. eCollection 2022. PMID: 35281013
Peripheral venous catheter-related candidemia in an immunocompetent child. Sudo Y, Kawamura Y, Miura H, Yokoi K, Yoshikawa T. Pediatr Int. 2022 Jan;64(1):e14883. doi: 10.1111/ped.14883. Epub 2021 Nov 30.
Detection of human herpesviruses in cerebrospinal fluids of patients suspected of central nervous system infection. Ishimaru S, Kawamura Y, Miura H, Shima S, Ueda A, Mutoh T, Yoshikawa T. J Neurovirol. 2021 Dec 30. doi: 10.1007/s13365-021-01040-5.
Meningitis Caused by the Live Varicella Vaccine Virus: Metagenomic Next Generation Sequencing, Immunology Exome Sequencing and Cytokine Multiplex Profiling. Ramachandran PS, Wilson MR, Catho G, Blanchard-Rohner G, Schiess N, Cohrs RJ, Boutolleau D, Burrel S, Yoshikawa T, Wapniarski A, Heusel EH, Carpenter JE, Jackson W, Ford BA, Grose C. Viruses. 2021 Nov 16;13(11):2286. doi: 10.3390/v13112286.
Epstein-Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV. Venturini C, Houldcroft C, Lazareva A, Wegner F, Morfopoulou S, Amrolia P, Golwala Z, Rao A, Marks S, Simmonds J, Yoshikawa T, Farrell P, Cohen J, Worth A, Breuer J. Brit J Haematol 2021 Oct;195(2):249-255. doi: 10.1111/bjh.17790.
A case of aseptic meningitis without skin rash caused by Oka Varicella Vaccine. Kawamura Y, Suzuki D, Kono T, Miura H, Kozawa K, Mizuno H, Yoshikawa T. Pediatr Infect Dis J. 2021 Aug 24. doi: 10.1097/INF.0000000000003316.
Full genome-based characterization of G4P[6] rotavirus strains from diarrheic patients in Thailand: Evidence for independent porcine-to-human interspecies transmission events. Tacharoenmuang R, Guntapong R, Upachai S, Singchai P, Fukuda S, Ide T, Hatazawa R, Sutthiwarakom K, Kongjorn S, Onvimala N, Luechakham T, Ruchusatsawast K, Kawamura Y, Sriwanthana B, Motomura K, Tatsumi M, Takeda N, Yoshikawa T, Murata T, Uppapong B, Taniguchi K, Komoto S. Virus Genes. 2021 Aug;57(4):338-357. doi: 10.1007/s11262-021-01851-y. Epub 2021 Jun 9.
Effect of Lactococcus lactis Strain Plasma on HHV-6 and HHV-7 Shedding in Saliva: A Prospective Observational Study. Miura H, Ihira M, Kozawa K, Kawamura Y, Higashimoto Y, Hattori F, Yoshikawa T. Microorganisms. 2021 Aug 8;9(8):1683. doi: 10.3390/microorganisms9081683.
Implementing vaccination policies based upon scientific evidence in Japan. Yoshikawa T. Vaccine. 2021 Aug 7:S0264-410X(21)00968-3.
Evaluation of varicella vaccine effectiveness during outbreaks in schools or nurseries by cross-sectional study. Kawamura Y, Hattori F, Higashimoto Y, Kozawa K, Yoshikawa T. Vaccine. 2021 May 18;39(21):2901-2905. doi: 10.1016/j.vaccine.2021.04.009. Epub 2021 Apr 22.
Inherited Chromosomally Integrated Human Herpesvirus 6 Is a Risk Factor for Spontaneous Abortion. Miura H, Kawamura Y, Ohye T, Hattori F, Kozawa K, Ihira M, Yatsuya H, Nishizawa H, Kurahashi H, Yoshikawa T. J Infect Dis. 2021 May 28;223(10):1717-1723. doi: 10.1093/infdis/jiaa606.
Involvement of brain structures in childhood epilepsy with centrotemporal spikes. Ito Y, Maki Y, Okai Y, Kidokoro H, Bagarinao E, Takeuchi T, Ohno A, Nakata T, Ishihara N, Okumura A, Yamamoto H, Maesawa S, Natsume J. Pediatr Int. 2022 Jan;64(1):e15001. doi: 10.1111/ped.15001.
Itpr1 regulates the formation of anterior eye segment tissues derived from neural crest cells. Kinoshita A, Ohyama K, Tanimura S, Matsuda K, Kishino T, Negishi Y, Asahina N, Shiraishi H, Hosoki K, Tomiwa K, Ishihara N, Mishima H, Mori R, Nakashima M, Saitoh S, Yoshiura KI. Development. 2021 Aug 15;148(16):dev188755. doi: 10.1242/dev.188755. Epub 2021 Aug 26.
Establishment of in-hospital clinical network for patients with neurofibromatosis type 1 in Nagoya University Hospital. Nishida Y, Ikuta K, Natsume A, Ishihara N, Morikawa M, Kidokoro H, Muramatsu Y, Nonobe N, Ishizuka K, Takeichi T, Kanbe M, Mizuno S, Imagama S, Ozaki N. Sci Rep. 2021 Jun 7;11(1):11933. doi: 10.1038/s41598-021-91345-6.
Hippocampal Atrophy in Pediatric Transplant Recipients with Human Herpesvirus 6B. Miyake M, Kawamura Y, Ishihara N, Suzuki S, Miura H, Sakaguchi Y, Tanaka M, Takahashi Y, Kojima S, Toyama H, Natsume J, Yoshikawa T. Microorganisms. 2021 Apr 8;9(4):776. doi: 10.3390/microorganisms9040776.
Salvage therapy with 2-chlorodeoxyadenosine for refractory and relapsed pediatric Langerhans cell histiocytosis: an updated nationwide survey in Japan. Taniguchi M, Sakamoto K, Shioda Y, Doi T, Kudo K, Fujino H, Kudo K, Morimoto A. Int J Hematol. 2021 Mar;113(3):461-463.
Coinfection With Human Herpesvirus (HHV)-6B in Immunocompetent, Healthy Individuals With Chromosomally Integrated HHV-6A. Miura H, Ohye T, Kozawa K, Hattori F, Kawamura Y, Ihira M, Kurahashi H, Yoshikawa T. J Pediatric Infect Dis Soc. 2021 Mar 26;10(2):175-178. doi: 10.1093/jpids/piaa009.
Immune response against SARS-CoV-2 in pediatric patients including young infants. Kawamura Y, Higashimoto Y, Miura H, Ihira M, Inaba M, Ito R, Kozawa K, Yoshikawa T. J Med Virol. 2021 Mar;93(3):1776-1779. doi: 10.1002/jmv.26493. Epub 2020 Sep 29.
Inherited chromosomally integrated human herpesvirus 6 and autoimmune connective tissue diseases. Kawamura Y, Hashimoto T, Miura H, Kozawa K, Yoshikawa A, Ikeda N, Yatsuya H, Yasuoka H, Yoshikawa T. J Clin Virol. 2020 Nov;132:104656. doi: 10.1016/j.jcv.2020.104656. Epub 2020 Oct 5.
Trend in varicella patients 4 years after implementation of universal two-dose varicella vaccination in Japan. Hattori F, Kozawa K, Miura H, Kawamura Y, Higashimoto Y, Yoshikawa A, Ihira M, Yoshikawa T; Nagoya VZV Study Group. Vaccine. 2020 Oct 27;38(46):7331-7336.
Molecular characterization of rotaviruses obtained from patients with rotavirus-associated encephalitis/encephalopathy. Ihira M, Kawamura Y, Miura H, Hattori F, Higashimoto Y, Sugata K, Ide T, Komoto S, Taniguchi K, Yoshikawa T. Microbiol Immunol. 2020 Aug;64(8):541-555. doi: 10.1111/1348-0421.12827. Epub 2020 Aug 4.
Three Adolescents With Primary Human Herpesvirus 7 Infection During a Measles Outbreak. Kono T, Hattori F, Kawamura Y, Miura H, Sudo Y, Suzuki M, Yoshikawa T. Pediatr Infect Dis J. 2020 Aug;39(8):e209-e211.
Clinical Features of Complex Febrile Seizure Caused by Primary Human Herpesvirus 6B Infection. Miyake M, Kawamura Y, Hattori F, Miura H, Ishihara N, Yoshikawa T. Pediatr Neurol. 2020 Aug;109:52-55. doi: 10.1016/j.pediatrneurol.2020.03.015. Epub 2020 Mar 28.
Frequency of subclinical herpes zoster in pediatric hematology-oncology patients receiving chemotherapy: A retrospective cohort analysis. Kozawa K, Miura H, Kawamura Y, Tanaka M, Kudo K, Higashimoto Y, Ihira M, Yoshikawa T. J Med Virol. 2020 Aug;92(8):1260-1265.
Rapid generation of rotavirus single-gene reassortants by means of eleven plasmid-only based reverse genetics. Fukuda S, Hatazawa R, Kawamura Y, Yoshikawa T, Murata T, Taniguchi K, Komoto S. J Gen Virol. 2020 Aug;101(8):806-815.
Endogenization and excision of human herpesvirus 6 in human genomes. Liu X, Kosugi S, Koide R, Kawamura Y, Ito J, Miura H, Matoba N, Matsuzaki M, Fujita M, Kamada AJ, Nakagawa H, Tamiya G, Matsuda K, Murakami Y, Kubo M, Aswad A, Sato K, Momozawa Y, Ohashi J, Terao C, Yoshikawa T, Parrish NF, Kamatani Y. PLoS Genet. 2020 Aug 10;16(8):e1008915. doi: 10.1371/journal.pgen.1008915. eCollection 2020 Aug.
Full genome characterization of novel DS-1-like G9P[8] rotavirus strains that have emerged in Thailand. Fukuda S, Tacharoenmuang R, Guntapong R, Upachai S, Singchai P, Ide T, Hatazawa R, Sutthiwarakom K, Kongjorn S, Onvimala N, Ruchusatsawast K, Rungnopakun P, Mekmallika J, Kawamura Y, Motomura K, Tatsumi M, Takeda N, Murata T, Yoshikawa T, Uppapong B, Taniguchi K, Komoto S. PLoS One. 2020 Apr 22;15(4):e0231099
Human herpesvirus-6B infection in pediatric allogenic hematopoietic stem cell transplant patients: Risk factors and encephalitis. Miura H, Kawamura Y, Hattori F, Tanaka M, Kudo K, Ihira M, Yatsuya H, Takahashi Y, Kojima S, Sakaguchi H, Yoshida N, Hama A, Yoshikawa T. Transpl Infect Dis. 2020 Feb;22(1):e13203.
Nationwide retrospective review of hematopoietic stem cell transplantation in children with refractory Langerhans cell histiocytosis. Kudo K, Maeda M, Suzuki N, Kanegae H, Ohga S, Ishii E, Shioda Y, Imamura T, Imashuku S, Tsunematsu Y, Endo M, Shimada A, Koga Y, Hashii Y, Noguchi M, Unoue M, Tabuchi K, Morimoto A, on behalf of The Histiocytosis study group of the Japanese Society of Pediatric Hematology/Oncology. International Journal of Hematology (2020) 111:137–148.