Department of Informative Clinical Medicine , Interdepartmental Clinical Collaboration Unit,
Faculty of Medical Sciences, Fujita Health University

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News & Topics

  • September 4, 2021
　A graduate student gave an oral presentation remotely at the 10th Annual Meeting of the Japanese DOHaD Society.
  • July 16, 2021
　A doctoral student submitted a paper to Nutrition Research and it was accepted.
  • April 1, 2021
　Five master's course students joined our group in the new school term.

Introduction

In this field, we mainly conduct basic research using cultured cells and various animal models using mice and rats. Based on the research results, we aim to apply them to clinical trials and establish novel biomarkers. In the Clinical Collaboration Unit, we are engaged in the clinical laboratory to analyze clinical datum and conduct cooperative research with medical scientists. At the graduate school, we hold research meetings to introduce papers related to our research themes and to discuss the progress of our research. Through these activities, we will develop independent human resources and people who can take on research position in clinical sites, universities, and companies.

Members

Faculty members

Medical Technology

Graduate student

Doctor’s course: Yoshitaka Ando (D3), Genki Mizuno (D3), Nanaka Morita (D2), Itsuki Kageyama (D1), Yuki Nouchi (D1)
Master’s course: Tomohide Sakakibara (M2), Takuya Wakasugi (M2), Miyuki Ikeya (M1), Hayato Ichikawa (M1), Masaki Oshiro (M1), Sayaka Yoshida (M1), Fumiaki Sato (M1)
Undergraduate course: Yuri Kamiya

Research Theme

・Effects of fructose intake during gestation and lactation on the next generation
・Elucidation of constitutional development from the viewpoint of epigenome
・Establishment of biomarkers for early detection metabolic disorders

Metabolic disorders are closely related to the onset of disease. We are elucidating the molecular mechanisms of disease onset by lifestyle factors such as dietary habits. In particular, we are focusing on epigenetics in our research. In addition, there are people who get diseases and people who do not get diseases despite living the same life. This phenomenon is called "constitution," but it has not been scientifically elucidated. Our goal is to scientifically clarify this "constitution" by using technologies in various fields such as biochemistry, molecular biology, and genetic engineering, and to develop new testing and prevention methods. Establishing biomarkers for diseases is another task that clinical laboratories are responsible for. We are also participating in epidemiological and clinical studies to search for biomarkers and establish new testing methods. We are also collaborating with Dr. Hiroya Yamada of the Department of Hygiene, Dr. Eiji Munetsuna of the Department of Biochemistry. (Ohashi, Ishikawa, Ando)

・The role of tryptophan and glucose metabolism in immune cells
・Establishment of novel biomarkers in chronic kidney disease
・The effects of rare sugars in various inflammatory diseases

Our research interests range from cancer treatment to kidney disease. As basic research, we focus on the metabolism of immune cells using various mouse models of inflammatory diseases. In particular, the recent advent of immune checkpoint inhibitors (ICIs) has dramatically improved cancer therapy, but many patients are refractory to ICIs. We aim to solve this problem. We also aim to establish biomarkers for diagnosis and prognosis by elucidating the pathogenesis of various renal diseases, including acute kidney injury, using clinical specimens and mouse models. Although urine sample can be collected without invasion, it contains many unknown components. Our goal is to contribute to kidney disease, which is one of the most common diseases in Japan. All of our research is closely linked to clinical practice, and we are working hard every day to apply our findings to humans. (Masato Hoshi)

Annual Events

Paper Abstracts and Progress Reports

We hold weekly meetings to introduce papers and report on research progress, mainly by graduate students.

Academic conferences Presentations

Academic conferences Presentations
We actively present the results of our research at domestic and international conferences. Graduate students also aim to present their research results at international conferences by the end of their studies.

Lab Camp

Lab Camp
Once a year during the summer vacation, we go camping with thesis students and graduate students. We enjoy BBQ and sightseeing in the cool mountains. Graduate students and thesis students who have graduated also come to visit us, and we can casually ask them about their experiences in the field.

Photo Gallery

  • Coming soon…

Academic Activities

Manuscripts

2021

  1. Nanaka Morita, Masato Hoshi, Takeshi Hara, Soranobu Ninomiya, Taisuke Enoki, Misao Yoneda, Hisashi Tsurumi and Kuniaki Saito. Viability of diffuse large B-cell lymphoma cells is regulated by kynurenine 3-monooxygenase activity. Oncology letters. In press.
  2. Ryosuke Fujii, Hiroya Yamada, Yoshiki Tsuboi, Yoshitaka Ando, Eiji Munetsuna, Mirai Yamazaki, Koji Ohashi, Hiroaki Ishikawa, Yuya Ishihara, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Association between circulating microRNAs and changes in kidney function: A five-year prospective study among Japanese adults without CKD. Clinica Chimica Acta. 521: 97-103, 2021.
  3. Yoshiki Tsuboi, Hiroya Yamada, Eiji Munetsuna, Ryosuke Fujii, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Hiroaki Ishikawa, Koji Ohashi, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Global DNA hypermethylation in peripheral blood mononuclear cells and cardiovascular disease risk: a population-based propensity score-matched cohort study. Journal of epidemiology and community health 75(9) :890-895, 2021.
  4. Genki Mizuno, Masato Hoshi, Kentaro Nakamoto, Masayo Sakurai, Kazuko Nagashima, Takashi Fujita, Hiroyasu Ito, Tadayoshi Hata. Evaluation of red blood cell parameters provided by the UF-5000 urine auto-analyzer in patients with glomerulonephritis. Clinical chemistry and laboratory medicine 59(9):1547-1553, 2021.
  5. Genki Mizuno, Eiji Munetsuna, Hiroya Yamada, Mirai Yamazaki, Yoshitaka Ando, Yuji Hattori, Itsuki Kageyama, Atsushi Teshigawara, Yuki Nouchi, Ryosuke Fujii, Hiroaki Ishikawa, Koji Suzuki, Shuji Hashimoto, Koji Ohashi, Yohei Shimono. Maternal fructose consumption downregulates hippocampal catalase expression via DNA methylation in rat offspring. Nutrition research. 92:40-48, 2021.
  6. Masato Hoshi, Hisako Kubo, Tatsuya Ando, Chieko Tashita, Kentaro Nakamoto, Yasuko Yamamoto, Hiroyuki Tezuka, Kuniaki Saito. 3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice. ImmunoHorizons 5(6):523-534, 2021.
  7. Yuko Mori, Akihiro Mouri, Kazuo Kunisawa, Mami Hirakawa, Hisayoshi Kubota, Aika Kosuge, Moe Niijima, Masaya Hasegawa, Hitomi Kurahashi, Reiko Murakami, Masato Hoshi, Takashi Nakano, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito. Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid. Behavioural brain research 405:113191-113191, 2021.
  8. Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Genki Mizuno, Yoshitaka Ando, Keisuke Maeda, Yoshiki Tsuboi, Koji Ohashi, Hiroaki Ishikawa, Chiharu Hagiwara, Kenji Wakai, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Dietary fish and ω-3 polyunsaturated fatty acids are associated with leukocyte ABCA1 DNA methylation levels. Nutrition. 81:110951-110951, 2021.

2020

  1. Koji Suzuki, Hiroya Yamada, Ryosuke Fujii, Eiji Munetsuna, Yoshitaka Ando, Koji Ohashi, Hiroaki Ishikawa, Mirai Yamazaki, Keisuke Maeda, Shuji Hashimoto, Nobuyuki Hamajima. Association between circulating vascular-related microRNAs and an increase in blood pressure: a 5-year longitudinal population-based study. Journal of hypertension 39(1) 84-89, 2021.
  2. Keisuke Maeda, Hiroya Yamada, Eiji Munetsuna, Ryosuke Fujii, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Hiroaki Ishikawa, Koji Ohashi, Yoshiki Tsuboi, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Association of smoking habits with TXNIP DNA methylation levels in leukocytes among general Japanese population. PLOS ONE. 15(7):e0235486-e0235486, 2020.
  3. Ayumi Yamada, Atsushi Teramoto, Yuka Kiriyama, Tetsuya Tsukamoto, Kazuyoshi Imaizumi, Masato Hoshi, Kuniaki Saito, Hiroshi Fujita. Automated classification method of lung tumor type using cytological image and clinical record. International Workshop on Advanced Imaging Technology. 2020 2020.
  4. Masato Hoshi, Yosuke Osawa, Kentaro Nakamoto, Nanaka Morita, Yasuko Yamamoto, Tatsuya Ando, Chieko Tashita, Toshitaka Nabeshima, Kuniaki Saito. Kynurenine produced by indoleamine 2,3-dioxygenase 2 exacerbates acute liver injury by carbon tetrachloride in mice. Toxicology. 438:152458-152458, 2020.
  5. Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Koji Ohashi, Hiroaki Ishikawa, Keisuke Maeda, Chiharu Hagiwara, Yoshitaka Ando, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Associations of Circulating MicroRNAs (miR-17, miR-21, and miR-150) and Chronic Kidney Disease in a Japanese Population. Journal of epidemiology. 30(4):177-182, 2020.
  6. Chieko Tashita, Masato Hoshi, Akihiro Hirata, Kentaro Nakamoto, Tatsuya Ando, Takayuki Hattori, Yasuko Yamamoto, Hiroyuki Tezuka, Hiroyuki Tomita, Akira Hara, Kuniaki Saito. Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice. World journal of gastroenterology. 26(9):918-932, 2020.
  7. Mirai Yamazaki, Eiji Munetsuna, Hiroya Yamada, Yoshitaka Ando, Genki Mizuno, Ryosuke Fujii, Hiroaki Ishikawa, Koji Suzuki, Yohei Shimono, Shuji Hashimoto, Koji Ohashi. Maternal fructose consumption downregulates Lxra expression via miR-206-mediated regulation. J Nutr Biochem. 2020.

2019

  1. Yoshitaka Ando, Mirai Yamazaki, Hiroya Yamada, Eiji Munetsuna, Ryosuke Fujii, Genki Mizuno, Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Hiroaki Ishikawa, Koji Ohashi, Ryoji Teradaira, Yoshiji Ohta, Nobuyuki Hamajima, Shuji Hashimoto, Koji Suzuki. Association of circulating miR-20a, miR-27a, and miR-126 with non-alcoholic fatty liver disease in general population. Scientific reports. 9(1):18856-18856, 2019.
  2. Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Genki Mizuno, Nao Sadamoto, Yoshitaka Ando, Ryosuke Fujii, Kazuya Shiogama, Hiroaki Ishikawa, Koji Suzuki, Yohei Shimono, Koji Ohashi, Shuji Hashimoto. Maternal fructose-induced oxidative stress occurs viaTfam and Ucp5 epigenetic regulation in offspring hippocampi. FASEB journal. 33(10):11431-11442, 2019.
  3. Wakana Yamasuge, Yasuko Yamamoto, Hidetsugu Fujigaki, Masato Hoshi, Kentaro Nakamoto, Kazuo Kunisawa, Akihiro Mouri, Toshitaka Nabeshima, Kuniaki Saito. Indoleamine 2,3-dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma. Cancer science. 110(10):3061-3067, 2019.
  4. Noguchi K, Tomita H, Kanayama T, Niwa A, Hatano Y, Hoshi M, Sugie S, Okada H, Niwa M, Hara A. Time-course analysis of cardiac and serum galectin-3 in viral myocarditis after an encephalomyocarditis virus inoculation. PloS one. 14(1):e0210971, 2019.
  5. Eiji Munetsuna, Hiroya Yamada, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Yuji Hattori, Nao Sadamoto, Hiroaki Ishikawa, Yoshiji Ohta, Ryosuke Fujii, Koji Suzuki, Shuji Hashimoto, Koji Ohashi. Maternal high-fructose intake increases circulating corticosterone levels via decreased adrenal corticosterone clearance in adult offspring. The Journal of nutritional biochemistry. 67:44-50, 2019.
  6. Hiroaki Ishikawa, Hiroya Yamada, Kanako Kondo, Takeru Ota, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Eiji Munetsuna, Koji Suzuki, Ryoji Teradaira, Koji Ohashi. Establishment of a simpler method for measuring HDL-microRNAs. Annals of clinical biochemistry. 56(1):49-55, 2019.

Access

  • Access to Informative Clinical Medicine 214, 3rd  ⇒ University Building 3

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