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トップページ >  事業成果 >  2017年度成果発表 >  医療科学部 病態制御解析学/先進診断システム探索研究部門

医療科学部 病態制御解析学/先進診断システム探索研究部門


発表論文

1
Tran HQ, Lee Y, Shin EJ, Jang CG, Jeong JH, Mouri A, Saito K, Nabeshima T, Kim HC: PKCδ Knockout Mice Are Protected from Dextromethorphan-Induced Serotonergic Behaviors in Mice: Involvements of Downregulation of 5-HT(1A) Receptor and Upregulation of Nrf2-Dependent GSH Synthesis. Mol Neurobiol. 2018 Feb 22. ( In Press)
2
Yamazaki M, Yamada H, Munetsuna E, Ishikawa H, Mizuno G, Mukuda T, Mouri A, Nabeshima T, Saito K, Suzuki K, Hashimoto S, Ohashi K: Excess maternal fructose consumption impairs hippocampal function in offspring via epigenetic modification of BDNF promoter. FASEB J. 2018 Jan( In Press)
3
Sobue A, Ito N, Nagai T, Shan W, Hada K, Nakajima A, Murakami Y, Mouri A, Yamamoto Y, Nabeshima T, Saito K, Yamada K: Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes. Glia. 2018 Jan( In Press)
4
Mai HN, Sharma N, Shin EJ, Nguyen BT, Nguyen PT, Jeong JH, Cho EH, Lee YJ, Kim NH, Jang CG, Nabeshima T, Kim HC: Exposure to far-infrared ray attenuates methamphetamine-induced impairment in recognition memory through inhibition of protein kinase C δ in male mice: Comparison with the antipsychotic clozapine. J Neurosci Res. 2018 Feb 24. ( In Press)
5
Tran HQ, Lee Y, Shin EJ, Jang CG, Jeong JH, Mouri A, Saito K, Nabeshima T, Kim HC.: PKCδ Knockout Mice Are Protected from Dextromethorphan-Induced Serotonergic Behaviors in Mice: Involvements of Downregulation of 5-HT(1A) Receptor and Upregulation of Nrf2-Dependent GSH Synthesis. Mol Neurobiol. 2018 Feb 22. ( In Press)
6
Kimura A, Takemura M, Serrero G, Yoshikura N, Hayashi Y, Saito K, Inuzuka T: Higher levels of progranulin in cerebrospinal fluid of patients with lymphoma and carcinoma with CNS metastasis. J Neurooncol. 2018 Jan( In Press)
7
Yamamoto Y, Goto N, Takemura M, Yamasuge W, Yabe K, Takami T, Miyazaki T, Takeuchi T, Shiraki M, Shimizu M, Adachi S, Saito K, Shibata Y, Nakamura N, Hara T, Serrero G, Saito K, Tsurumi H: Association between increased serum GP88 (progranulin) concentrations and prognosis in patients with malignant lymphomas. Clin Chim Acta. 2017 Oct ; 473:139-146.
8
Kubo H, Hoshi M, Matsumoto T, Irie M, Oura S, Tsutsumi H, Hata Y, Yamamoto Y, Saito K: Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice. Lipids Health Dis. 2017 Jun 3;16(1):106.
9
Kimura A, Takemura M, Saito K, Serrero G, Yoshikura N, Hayashi Y, Inuzuka T: Increased cerebrospinal fluid progranulin correlates with interleukin-6 in the acute phase of neuromyelitis optica spectrum disorder. J Neuroimmunol. 2017 Apr 15 ; 305:175-181.
10
Shibata Y, Hara T, Matsumoto T, Nakamura N, Nakamura H, Ninomiya S, Kitagawa J, Goto N, Nannya Y, Ito H, Kito Y, Miyazaki T, Takeuchi T, Saito K, Seishima M, Takami T, Moriwaki H, Shimizu M, Tsurumi H: Serum concentrations of l-kynurenine predict clinical outcomes of patients with peripheral T-cell lymphoma, not otherwise specified. Hematol Oncol. 2017 35(4):637-644.
11
Mouri A, Ukai M, Uchida M, Hasegawa S, Taniguchi M, Ito T, Hida H, Yoshimi A, Yamada K, Kunimoto S, Ozaki N, Nabeshima T, Noda Y: Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis. Neuropharmacology. 2018 Jan 11;133:23-37.
12
Dang DK, Shin EJ, Kim DJ, Tran HQ, Jeong JH, Jang CG, Ottersen OP, Nah SY, Hong JS, Nabeshima T, Kim HC: PKC-dependent p47phox activation mediates methamphetamine-induced dopaminergic neurotoxicity. Free Radic Biol Med. 2018 Feb 1;115:318-337. .
13
Shan W, Nagai T, Tanaka M, Itoh N, Furukawa-Hibi Y, Nabeshima T, Sokabe M, Yamada K: Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the induction of Homer1a. J Neurochem. 2017 Dec 9 ( In Press )
14
Sumi K, Uno K, Noike H, Tomohiro T, Hatanaka Y, Furukawa-Hibi Y, Nabeshima T, Miyamoto Y, Nitta A: Behavioral impairment in SHATI/NAT8L knockout mice via dysfunction of myelination development. Sci Rep. 2017 Dec 4;7(1):16872.
15
Toriumi K, Tanaka J, Mamiya T, Alkam T, Kim HC, Nitta A, Nabeshima T: Shati/Nat8l knockout mice show behavioral deficits ameliorated by atomoxetine and methylphenidate. Behav Brain Res. 2018 Feb 26;339:207-214.
16
Nguyen PT, Shin EJ, Dang DK, Tran HQ, Jang CG, Jeong JH, Lee YJ, Lee HJ, Lee YS, Yamada K, Nabeshima T, Kim HC: Role of dopamine D1 receptor in 3-fluoromethamphetamine-induced neurotoxicity in mice. Neurochem Int. 2018 Feb;113:69-84.
17
Tran TV, Park SJ, Shin EJ, Tran HQ, Jeong JH, Jang CG, Lee YJ, Nah SY, Nabeshima T, Kim HC: Blockade of platelet-activating factor receptor attenuates abnormal behaviors induced by phencyclidine in mice through down-regulation of NF-κB. Brain Res Bull. 2018 Mar;137:71-78.
18
Tran TV, Shin EJ, Dang DK, Ko SK, Jeong JH, Nah SY, Jang CG, Lee YJ, Toriumi K, Nabeshima T, Kim HC: Ginsenoside Re protects against phencyclidine-induced behavioral changes and mitochondrial dysfunction via interactive modulation of glutathione peroxidase-1 and NADPH oxidase in the dorsolateral cortex of mice. Food Chem Toxicol. 2017 Dec;110:300-315.
19
Itoh N, Nagai T, Watanabe T, Taki K, Nabeshima T, Kaibuchi K, Yamada K: Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein. Biochem Biophys Res Commun. 2017 Dec 2;493(4):1384-1389.
20
Tran HQ, Chung YH, Shin EJ, Tran TV, Jeong JH, Jang CG, Nah SY, Yamada K, Nabeshima T, Kim HC: MK-801, but not naloxone, attenuates high-dose dextromethorphan-induced convulsive behavior: Possible involvement of the GluN2B receptor. Toxicol Appl Pharmacol. 2017 Nov 1;334:158-166.
21
Matsumoto Y, Niwa M, Mouri A, Noda Y, Fukushima T, Ozaki N, Nabeshima T: Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable mice. Psychopharmacology (Berl). 2017 Oct;234(20):3055-3074.
22
Tran TV, Shin EJ, Nguyen LTT, Lee Y, Kim DJ, Jeong JH, Jang CG, Nah SY, Toriumi K, Nabeshima T, Yamada K, Kim HC: Protein Kinase Cδ Gene Depletion Protects Against Methamphetamine-Induced Impairments in Recognition Memory and ERK(1/2) Signaling via Upregulation of Glutathione Peroxidase-1 Gene. Mol Neurobiol. 2017 Jun 9. (In Press)
23
Shin EJ, Tran HQ, Nguyen PT, Jeong JH, Nah SY, Jang CG, Nabeshima T, Kim HC: Role of Mitochondria in Methamphetamine-Induced Dopaminergic Neurotoxicity: Involvement in Oxidative Stress, Neuroinflammation, and Pro-apoptosis-A Review. Neurochem Res. 2018 Jan;43(1):57-69.
24
Mouri A, Noda Y, Niwa M, Matsumoto Y, Mamiya T, Nitta A, Yamada K, Furukawa S, Iwamura T, Nabeshima T: The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization. Behav Brain Res. 2017 ;329:157-165.
25
Dang DK, Shin EJ, Tran HQ, Kim DJ, Jeong JH, Jang CG, Nah SY, Sato H, Nabeshima T, Yoneda Y, Kim HC: The role of system Xc(-) in methamphetamine-induced dopaminergic neurotoxicity in mice. Neurochem Int. 2017;108:254-265.
26
Li ZY, Chung YH, Shin EJ, Dang DK, Jeong JH, Ko SK, Nah SY, Baik TG, Jhoo JH, Ong WY, Nabeshima T, Kim HC: YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by ホイ-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2. J Neuroinflammation. 2017 ;14(1):94. doi: 10.1186/s12974-017-0866-x.
27
Dang DK, Shin EJ, Mai AT, Jang CG, Nah SY, Jeong JH, Ledent C, Yamamoto T, Nabeshima T, Onaivi ES, Kim HC: Genetic or pharmacological depletion of cannabinoid CB1 receptor protects against dopaminergic neurotoxicity induced by methamphetamine in mice. Free Radic Biol Med. 2017 Jul;108:204-224.
28
Shin EJ, Dang DK, Tran TV, Tran HQ, Jeong JH, Nah SY, Jang CG, Yamada K, Nabeshima T, Kim H: Current understanding of methamphetamine-associated dopaminergic neurodegeneration and psychotoxic behaviors. Arch Pharm Res. 2017 ;40(4):403-428.
29
Alkam T, Mamiya T, Kimura N, Yoshida A, Kihara D, Tsunoda Y, Aoyama Y, Hiramatsu M, Kim HC, Nabeshima T: Prenatal nicotine exposure decreases the release of dopamine in the medial frontal cortex and induces atomoxetine-responsive neurobehavioral deficits in mice. Psychopharmacology (Berl). 2017 Jun;234(12):1853-1869.
30
Tran TV, Shin EJ, Jeong JH, Lee JW, Lee Y, Jang CG, Nah SY, Lei XG, Toriumi K, Yamada K, Nabeshima T, Kim HC: Protective potential of the glutathione peroxidase-1 gene in abnormal behaviors induced by phencyclidine in mice. Mol Neurobiol. 2017 Nov;54(9):7042-7062.
31
Tashiro T, Murakami Y, Mouri A, Imamura Y, Nabeshima T, Yamamoto Y, Saito K: Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions. Behav Brain Res. 2017 Jan 15 ;317:279-285.

学会発表

1
Kuniaki Saito:Depressive symptoms and L-Tryptophan -Kynurenine pathway metabolism focus on neuro-inflammation. The 5th Congress of Asian College pof Neuropsychopharmacology( 2017.4.27-29, Indonesia)
2
Akihiro Mouri: The Ubiquitination of serotonin transporter in lymphoblasts derived from fluvoxamine-resistant depression patients. The 5th Congress of Asian College pof Neuropsychopharmacology(2017.4.27-29, Indonesia)
3
Norimichi, Itoh; Taku, Nagai; Akira, Sobue; Daisuke, Ibi; Akira, Nakajima; Toshitaka, Nabeshima; Kiyofumi, Yamada: Up-regulation of astrocyte-derived immune-related genes contributes to behavioral impairment. The 26th Annual Meeting of the International Behavioral Neuroscience Society (2017.6. 26-30 , Hiroshima)
4
Bolati, Wulaer; Taku, Nagai; Akira, Sobue; Keisuke, Kuroda; Kozo, Kaibuchi; Toshitaka Nabeshima; Kiyofumi, Yamada: Impaired visual discrimination learning in Disc1-knockout mice, reversed by clozapine treatment. The 26th Annual Meeting of the International Behavioral Neuroscience Society (2017.6. 26-30 , Hiroshima)
5
Akira, Sobue; Norimichi, Ito; Kazuhiro, Hada; Akira, Nakajima; Toshitaka, Nabeshima; Taku, Nagai; Kiyofumi, Yamada: Exosomal MHCI derived from astrocytes leads to behavioral and neuropathological abnormalities in mice. The 26th Annual Meeting of the International Behavioral Neuroscience Society (2017.6. 26-30 , Hiroshima)
6
祖父江顕、伊藤教道、単 偉、羽田和弘、中島晶、村上由希、毛利彰宏、山本康子、鍋島俊隆、齋藤邦明、永井拓、山田清文: 抹消免疫活性が及ぼすマウス大脳皮質における免疫関連因子の発現誘導 第131回薬理学会近畿部会(2017.6.30.名古屋)
7
齋藤邦明:(講演)免疫調節因子IDOを基軸とした創薬・新薬開発 婦人科腫瘍研究会(2017.7.7 浜松 )
8
齋藤邦明:(講演)脳神経疾患における治療標的としてのトリプトファン-キヌレニン代謝酵素」第23回脳の医学・生物学研究会(2017.8.17名古屋)  
9
國澤和生、毛利彰宏、藤垣英嗣、山本康子、星雅人、鈴木康司、市野直浩、秋山秀彦、鍋島俊隆、齋藤邦明: 大学院での研究活性化の取り組みー領域制の確立と寄附研究部門の開設ー. 第12回日本臨床検査学教育学会学術大会(2017.8.23-25.埼玉)
10
森美奈、間宮隆吉、野口七瀬、大谷駿人、衣斐大祐、鍋島俊隆、平松正行:注意欠如多動性障害モデルに対するガランタミンの作用 生体機能と創薬シンポジウム2017(2017.8.24 , 京都)
11
古関竹直,谷川郁惠,毛利彰宏,山田成樹,齋藤邦明,岩田仲生: レギュラトリーサイエンスの素養を持つ臨床研究コーディネーターの養成について 第17回CRCと臨床試験のあり方を考える会議 2017 in 名古屋( 2017.9.2-3 名古屋)
12
Taku Nagai,Wei Shan, Motoki Tanaka, Toshitaka Nabeshima, Masahiro SHikaba, Kiyofumi Yamada: Npas4 mediates pentylenetetrazole-induced Homer1a expression in the hippocampus. 第60回日本神経化学会大会 (2017.9.7-9, 仙台)
13
小泉光, 毛利彰宏, 鍋島俊隆, 征矢英昭: 発育期の運動習慣は統合失調症の軽減に有効か:認知機能障害への効果 第72回日本体力医学会大会 (2017.9.16-17 松山)
14
永井拓,SHANWEI,田中基樹,鍋島俊隆,曽我部正博,山田清文: ペンチレンテトラゾール誘発てんかん発作におけるNpas4の役割 日本生物学的精神医学会 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会(2017. 9.28-30 札幌)
15
新田淳美,鷲見和之,友廣岳則,畑中保丸,日比陽子,宮本嘉明,鍋島俊隆,宇野恭介: 幼若期のミエリン形成の遅延によるSHATI/NAT8L KOマウスの社会性低下や不安作用の増大 日本生物学的精神医学会 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会 (2017. 9.28-30 札幌)
16
祖父江顕,伊藤教道,羽田和弘,中島晶,村上由希,毛利彰宏,山本康子,鍋島俊隆,齋藤邦明,永井拓,山田清文: アストログリアにおけるMHCIの発現とその行動学的・神経病理学的影響 日本生物学的精神医学会 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会(2017. 9.28-30 札幌)
17
藤垣英嗣、吉田幸弘、山本康子、齋藤邦明: Kynurenine 3-monooxygenase遺伝子R452C変異解析の基礎的検討.第57回日本臨床化学会年次学術集会(2017.10.06-08 北海道)
18
吉田幸弘、藤垣英嗣、山本康子、齋藤邦明: 酵素法を用いたキヌレニン定量法の開発.第57回日本臨床化学会年次学術集会 ( 2017.10.06-08 北海道)
19
石田秀和,竹村正男,桜井雅史,鈴木康司,竹田真由,和田久泰,林慎,松波英寿,野久謙,伊藤弘康,清島満,齋藤邦明: LDLコレステロール値における直接法とFriedewald式の乖離原因追究と新予測式の開発 第57回日本臨床化学会年次学術集会(2017.10.06-08 北海道)
20
竹村正男、佐藤正夫、伊藤弘養、 清島 満、齋藤邦明: RA患者の血中インフリキシマブ濃度測定の意義」第64回日本臨床検査医学会学術集会(2017.11.18 京都)
21
Norimichi Itoh, Taku Nagai, Daisuke Ibi, Akira Nakajima, Toshitaka Nabeshima, Kiyofumi Yamada: Ifitm3 regulates polyI: C -induced neuronal impairment via rab small gtpases.
22
(Neuroscience 2017, 11.11-15, Washington DC)
23
Boltani Wulaer, Taku Nagai, Akira Sobue, Kensuke Kuroda, Kozo Kaibuchi, Toshitaka Nabeshima, Kiyofumi Yamada: Cognitive deficit correlated with changes in neuronal activitiy in Disc1 delta 2-3/delta 2-3 mice in touchscreen-based visual discrimination task. (Neuroscience 2017, 11.11-15, Washington DC)
24
山﨑杏佳、藤垣英嗣、吉田幸弘、山本康子、齋藤邦明: Kynurenine 3-monooxygenaseのN結合型糖鎖修飾の検出.第14回 糖鎖「若手の力フォーラム」(2017.11.11 愛知)
25
伊藤愛、間宮隆吉、加藤俊佑、森美奈、衣斐大祐、鍋島俊隆、平松正行:胎生期ニコチン曝露誘発行動障害に対するガランタミンの作用:ドパミンD1受容体の関与 第132回日本薬理学会近畿部会(2017.11.24大阪)
26
吉田幸弘、藤垣英嗣、山﨑杏佳、山本康子、齋藤邦明: Kynurenine aminotransferase 2を用いたキヌレニン測定法の開発.第38回日本トリプトファン研究会学術集 (2017.12.2-3 愛知)
27
竹村正男、佐藤正夫、伊藤弘康、清島 満、齋藤邦明: 生物学的製剤の血中濃度はRA治療効果を反映しているか? 第67回日本臨床検査医学会東海・北陸支部総会 第336回日本臨床化学会東海・北陸支部例会(2018.3.11 金沢)