yŽ¾Š³ƒ‚ƒfƒ‹‹³ˆçŒ¤‹†ƒZƒ“ƒ^[@‹ÆÑ2001`2005z


‰¢•¶ŽGŽ

Nagao, S., Kusaka, M., Nishii, K., Marunouchi, T., Kurahashi, H., Takahashi, H., Grantham, JJ. Androgen receptor pathway in rats with autosomal dominant polycystic kidney disease. J. Am. Soc. Nephrol. 16(7):2052-2062. (2005)

Ota, M., Mori, K., Nakashima, A., Kaneko, Y., Takahashi, H., Ota, A. Resistance to excessive bodyweight gain in risperidone-injected rats. Clin. Exp. Pharmacol. Physiol. 32(4):279-287.i2005)

Mori, K., Kaneko, Y., Nakashima, A., Nagatsu,I., Takahashi, H., Ota, A. Peripheral lipopolysaccharide induces apoptosis in the murine olfactory bulb. Brain Res. 1039(1-2):116-129.i2005j

Utsumi, M., Moriguchi, K., Takahashi, H., Kinoshita, C., Togari, A., Mizutani, M., Ohno, N. Age-related changes of the ultrastructure in the cardiomyopathic hamster (UM-X7.1 Syrian hamster) parathyroid gland. Histol. Histopathol. 19(3):815-821. (2004)

Masunaga, R., Nagasaka, A., Sawai, Y., Hayakawa, N., Nakai, A., Hotta, K., Kato, Y., Hishida, H., Takahashi, H., Naka, M., Shimada, Y., Tanaka, T., Hidaka, H., Itoh, M. Changes in cyclic nucleotide phosphodiesterase activity and calmodulin concentration in heart muscle of cardiomyopathic hamsters. J. Mol. Cell. Cardiol. 37(3):767-774.i2004)

Sugiura, K., Hiramoto, K., Shamoto, M., Sugiura, M., Hayakawa, R., Kato, Y., Shinzato, M., Osada, A., Sakamoto, N., Takahashi, H.Immunological cell situation in the skin of atopic model mice. J. Eur .Acad. Dermatol. Venereol. 18(2):148-152. (2004)

Nagao, S., Yamaguchi, T., Kusaka, M., Takahashi, H., Grantham, JJ. Renal activation of extracellular-signal-regulated-kinase inn rats with autosomal dominant polycystic kidney disease. Kidney Int. 63(2):427-437. (2003)

Yamaguchi, T., Nagao, S., Wallace, D., Belibi, F., Cowley, B Jr., Pelling, J., Grantham, JJ. Cyclic AMP Activates B-Raf and ERK in Cyst Epithelial Cells from Autosomal Dominant Polycystic Kidneys. Kidney Int. 63(6):1983-1994. (2003)

Kanno, Y., Okada, H., Moriwaki, K., Nagao, S., Takahashi, H., Suzuki, H. The effects of antihypertensive agents on the survival rate of polycystic kidney disease in Han:SPRD rats.Hypertens.Res. 25(6):939-943. (2002)

Mizutani, M., Utsumi, M., Moriguchi, K., Takahashi, H., Kinoshita, C., Togari, A., Saruwatari, L., Ohno, N. Histopathologic Features of Masseter Muscle in the Distrophic Hamster (UM-X7.1 Syrian Hamster). Okajimas Folia Anat Jpn. 78(1):31-38. (2001)

Ishiguro, H., Yamada, K., Sawada, H., Nishii, K., Ichino, N., Sawada, M., Kurosawa, Y., Matsushita, N., Kobayashi, K., Goto, J., Hashida, H., Matsuda, N., Kanazawa, I., Nagatsu, T. Age-dependent and tissue-specific CAG repeat instability occurs in mouse knock-in for a mutant Huntington's disease gene. J. Neurosci. Res. 65(4):289-97. (2001)

Cowley, BD Jr., Richard, SD., Nagao, S., Diamond, JR. Increased renal expression of monocyte chemoattractant protein-1 and osteopontin in ADPKD in rats. Kidney Int. 60(6):2087-2096. (2001)


˜a•¶ŽGŽ

’·”öÃŽqA‚‹´‹v‰p@‘½”­«”Xtǃ‚ƒfƒ‹ ×–E@35(1):18-21. (2003)

ŽRŒû‘¾”ü—YA’·”öÃŽqAŠ}Œ´³’j@‘½”­«”X–Et@Annual Review 2003 t‘Ÿ 122-128. (2003)


˜a•¶–{

‚‹´‹v‰p@ƒ‚ƒfƒ‹“®•¨‚̈笂Ɨ˜—p@pp.77-92. ¬o@‹PA“ŒŒ´‰p“ñ@iŠÄCj ‘½”­«”X–Et\ˆâ“`Žq‚©‚çƒxƒbƒhƒTƒCƒh‚Ü‚Å@“ìŽR“°A“Œ‹ž@(2001)


‘ÛŠw‰ïE“Á•Êu‰‰“™

Nagao, S., Nishii, K., Yagyu, S., Kurahashi, H., Marunouchi, T., Takahashi, H., Katsuyama, M. Increased Water Intake and Urination Decreases Renal Enlargement in Rodent Autosomal Recessive PKD. 3rd World Congress ofNephrology,Singapore,Singapore (2005)

Suzuki, A., Yasuda, K., Caverzasio, J., Ono, Y., Sekiguchi, S., Nagao, S., Takahashi, H., Matsuyama, M., Yan, K., Kaneko, R., Hirabayashi, M., Ammann, P., Rizzoli, R., Oiso, Y., Itoh, M. Unanticipated development of cataract and nephritic syndrome in transgenic rats overexpressing type ‡V Na-dependent Phosphate transporter. American Society for Bone and Mineral Research 27th Annual Meeting,Nashville,TNUSA (2005)

Nagao, S., Nishii, K., Yagyu, S., Katsuyama, M., Hedge, AM., Kurahashi, H., Marunouchi, T., Takahashi, H., Wallace, DP. Increased Water Intake Redused Progression of Polycystic Kidney Disease in the PCK Rat. American Society of Nephrology 38th Annual Meeting & Scientific Exposition,Philadelphia,PAUSA (2005)

Nishii, K., Nagao, S., Yagyu, S., Katsuyama, M., Kurahashi, H., Marunouchi, T., Takahashi, H., Wallace, DP. Verapamil Inhibition of L-type Calcium Channels Enhances Polycystic Kidney Disease Progression in the Cy/+ Rat. American Society of Nephrology 38th Annual Meeting & Scientific Exposition,Philadelphia,PA USA (2005)

Nagao, S., Nishii, K., Yagyu, S., Katsuyama, M., Hedge, AM., Kurahashi, H., Marunouchi, T., Takahashi, H.,Wallace, PD. AVP-suppression ameliorates disease progression in rodent ARPKD. 1st Congress of Asian Society for Pediatric Research,Tokyo,Japan (2005)

Nagao, S., Nishii, K., Yagyu, S., Takahashi, H., Grantham, JJ. Relationship between Androgen Receptor and Src Activity in cystic Kidney DiseaseAmerican Society of Nephrology 37th Annual Meeting & Scientific Exposition, St.Louis, MO USA (2004)

Yamada, K., Hida, T., Sawada, H., Nishii, K., Ichino, N., Kurosawa, Y., Ishiguro, H., Nagatsu, T. Analysis of HD gene knock-in mouse and anti-htt single chain antibodies may be usefull for genetherapy of polyglutamine disease. 16th International Congress of the International Federation of Associations of Anatomists,Kyoto,Japan (2004)

Nagao, S., Kusaka, M., Takahashi, H., Grantham, JJ. Role of androgen receptor pathway in the progression of autosomal dominant polycystic kidney disease (ADPKD), World Congress of Nephrology, Berlin, Germany (2003)

Nagao, S., Nishii, K., Kusaka, M., Takahashi, H., Grantham, JJ. Efects of Flutamide, an Antagonist of Teststerone, on Androgen Receptor Expression and Disease Progression in Rodent Autosomal Dominant polycystic Kidney Disease. American Society of Nephrology 36th Annual Meeting & Scientific Exposition,San Diego,CA USA (2003)

Nagao, S., Kusaka, M., Takahashi, H., Grantham, JJ. Enhancded Expression of Androgen Receptor in Rats with Autosomal Dominant PKD. American Society of Nephrology 35th Annual Meeting & Scientific Exposition,Philadelphia,PA USA (2002)

Ishiguro, H., Sawada, H., Nishii, K., Yamada, K., Nagatsu, T. Neuronal internuclear inclusions locate specifically in the striatum and nucleus accumbens area of HD gene knock-in mouse. 32th Annual meeting of society for neuroscience,Orland,FL USA (2002)

Nagao, S., Yamaguchi, T., Kusaka, M., Wallace, DP., Belibi, FA., Cowley, BD Jr., Pelling, JC., Grantham, JJ. Evidence of a Role for Renal Extracellular-Regulated Kinase (ERK) Activation in Rats with Spontaneous Autosomal Dominant Polycystic Kidney Disease (ADPKD). American Society of Nephrology 34th Annual Meeting & Scientific Exposition,San Francisco,CA USA (2001)

Yamaguchi, T., Nagao, S., Wallace, DP., Belibi, FA., Cowley, BD Jr., Pelling, JC., Grantham, JJ. cAMP Activates Extracellular Signal-Regulated Kinase (ERK) through B-Raf Kinase Activation in Autosomal Dominant Polycystic Kidney Epithelial Cells. American Society of Nephrology 34th Annual Meeting & Scientific Exposition,San Francisco,CA USA (2001)


‘“àŠw‰ïE“Á•Êu‰‰“™

¼ˆäˆêGA’·”öÃŽqA–ö¶@–ÎAŸŽR@TAŠÛ–ì“àž¦A‚‹´‹v‰pAGrantham JJ ”X–E«t‘ŸŽ¾Š³ƒ‚ƒfƒ‹‚É‚¨‚¯‚é…•ªÛŽæ‚̉e‹¿‚ɂ‚¢‚Ä@‘æ52‰ñ“ú–{ŽÀŒ±“®•¨Šw‰ï‘‰ï@“Œ‹ž (2005)

’·”öÃŽqA–ö¶@–ÎA¼ˆäˆêGA‚‹´‹v‰pAGrantham JJ ”X–E«tŽ¾Š³‚É‚¨‚¯‚éCahR܂̉e‹¿ ‘æ48‰ñ“ú–{t‘ŸŠw‰ïŠwp‘‰ï@_“Þì (2005)

“ú”ä–ì‹ÎA–ö“c—²³AŽR–{’¼Ž÷A‹gŒ´‘å•ãA’·”öÃŽqA‚‹´‹v‰p@‘½”A‚ð“Á’¥‚Æ‚µ‚½‰¼Ì icn ƒ}ƒEƒX‚ɂ‚¢‚Ä@‘æ22‰ñ“ú–{Ž¾Š³ƒ‚ƒfƒ‹Šw‰ï@ŒQ”n (2005)

¼ˆäˆêGA’·”öÃŽqA’·‰ª•S‡A‰Í˜aŠ°ŒbAŒüŒã@Š°A‘q‹´_Ž÷A‚‹´‹v‰p@”X–E«t‘ŸŽ¾Š³ƒ‚ƒfƒ‹“®•¨‚Å‚ ‚é‚o‚b‚jƒ‰ƒbƒg‚ÌŠî‘b“Iƒf[ƒ^‚̉ðÍ@‘æ28‰ñ“ú–{•ªŽq¶•¨Šw‰ï”N‰ï •Ÿ‰ª (2005)

‰Hª“cç]”üA‚‹´‹v‰p@S‹Øǃnƒ€ƒXƒ^[UM-X7.1‚É‚¨‚¯‚éCa“Š—^‚̉e‹¿@‘æ39‰ñ“ú–{ŽÀŒ±“®•¨‹ZpŽÒ‹¦‰ï‘‰ï@Îì (2005)

’·”öÃŽqAŽR–{’¼Ž÷A¼ˆäˆêG@ŠÛ–ì“àž¦A‚‹´‹v‰p@”X–E«t‘ŸŽ¾Š³‚É‚¨‚¯‚é×–E‘B@ŠÔŽ¿‘‰Á‚ƃAƒ|ƒg[ƒVƒX‚ÌŠÖŒW@‘æ51‰ñ“ú–{ŽÀŒ±“®•¨Šw‰ï‘‰ï ’·è (2004)@

’·”öÃŽqA¼ˆäˆêGAGrantham JJA‚‹´‹v‰p@”X–E«tŽ¾Š³‚Ìis‚ƃzƒ‹ƒ‚ƒ“@‘æ47‰ñ“ú–{t‘ŸŠw‰ïŠwp‘‰ï “È–Ø (2004)

’·”öÃŽqA¼ˆäˆêGAŠÛ–ì“àž¦A‚‹´‹v‰p@”X–E«t‘ŸŽ¾Š³ƒ‰ƒbƒg‚Ì•a‘Ôis‚É‚¨‚¯‚é×–Eî•ñ“`’BŒo˜H‚̉ð͂ɂ‚¢‚Ä@‘æ21‰ñ“ú–{Ž¾Š³ƒ‚ƒfƒ‹Šw‰ï‘‰ï‹ž“s (2004)

¼ˆäˆêGA‚‹´‹v‰pA’·”öÃŽq@”X–E«t‘ŸŽ¾Š³ƒ‚ƒfƒ‹ƒ}ƒEƒX‚ÌÓ”Cˆâ“`Žq—̈æ‚ÌŒŸõ@‘æ51‰ñ“ú–{ŽÀŒ±“®•¨Šw‰ï‘‰ï ’·è (2004)

¼ˆäˆêGA’·”öÃŽqA’·‰ª•S‡A‰Í˜aŠ°ŒbAŽR“cWŽiAŒüŒã@Š°A‘q‹´_Ž÷A‚‹´‹v‰p@”X–E«t‘ŸŽ¾Š³‚̃‚ƒfƒ‹“®•¨‚Å‚ ‚épcyƒ}ƒEƒX‚ÌÓ”Cˆâ“`Žq‚ɂ‚¢‚ẲðÍ@‘æ27‰ñ“ú–{•ªŽq¶•¨Šw‰ï”N‰ï •ºŒÉ (2004)

ŽR“cWŽiAŽs–ì’¼_A¼ˆäˆêGAàV“c_GA”ì“cŠx•FAΕŒ[ŽiA‰i’ÃrŽ¡@ƒjƒRƒ`ƒ“‚Å—U“±‚³‚ê‚é×–E“àƒVƒOƒiƒ‹“`’B‚ÉŠÖ‚·‚éˆâ“`ŽqŒQ‚̉ðÍ@‘æ27‰ñ“ú–{•ªŽq¶•¨Šw‰ï”N‰ï •ºŒÉ (2004)

’r–쳎jA—é–ØL‘ìA¼ˆäˆêGAˆÉ“¡ŽO‰hŽqA‰ªèPŽq ƒqƒglHõF‘Ì‚ð—˜—p‚µ‚½õF‘Ì‹@”\‰ðÍ@‘æ27‰ñ“ú–{•ªŽq¶•¨Šw‰ï”N‰ï •ºŒÉ (2004)

‰Hª“cç]”üA‚‹´‹v‰p@“î‚wü”­¶‘•’u‚ÌÝ’u@‘æ38‰ñ“ú–{ŽÀŒ±“®•¨‹ZpŽÒ‹¦‰ï‘‰ï ’·è (2004)

’·”öÃŽqA‚‹´‹v‰pAGrantham JJ t‘ŸŽ¾Š³ƒ‚ƒfƒ‹‚ÌŽ¾•ais‚ÉŠÖ‚í‚éƒzƒ‹ƒ‚ƒ“‚̉e‹¿@‘æ50‰ñ“ú–{ŽÀŒ±“®•¨Šw‰ï‘‰ï@é‹Ê (2003)

—é–ØL‘ìA’r–쳎jA¼ˆäˆêGAŽR–{‹±ŽqAˆÉ“¡ŽO‰hŽqA‰ªèPŽq@lHõF‘Ì‚ð—˜—p‚µ‚½ƒqƒgƒÀ-globin ˆâ“`Žq“±“üƒ}ƒEƒX‚Ì컂ƉðÍ@‘æ26‰ñ“ú–{•ªŽq¶•¨Šw‰ï”N‰ï@•ºŒÉ@(2003)

‰Hª“cç]”üA…–ì‘P•¶A‚‹´‹v‰p@ˆâ“`«œˆÙí twy ƒ}ƒEƒX‚É‚¨‚¯‚é‘SŒŒƒ}ƒ‹ƒ`ƒ[ƒ^[ŒŸ¸Œ‹‰Ê@‘æ37‰ñ“ú–{ŽÀŒ±“®•¨‹ZpŽÒ‹¦‰ï‘‰ï@é‹Ê (2003)

’·”öÃŽqA‚‹´‹v‰p@ˆâ“`«”X–E«tŽ¾Š³Œ¤‹†‚Ìi•à@ADPKD ƒ‚ƒfƒ‹‚É‚¨‚¯‚é”X–E”­¶‹@˜‚Æ•a‘Ôis‚̉ðÍ@‘æ45‰ñ“ú–{t‘ŸŠw‰ï‘‰ï@‘åã@(2002)

’·”öÃŽqA…–ì‘P•¶A‚‹´‹v‰pAGrantham JJ ƒ‰ƒbƒg‘½”­«”X–EtÇ‚Ìt‘Ÿ‚É‚¨‚¯‚éMAPKinase ×–Eî•ñ“`’BŒn‚ÌŠÖ—^@‘æ49‰ñ“ú–{ŽÀŒ±“®•¨Šw‰ï‘‰ï@ˆ¤’m@(2002)

àV“c_GA¼ˆäˆêGAŽR“cWŽiAŒã“¡‡A‹ààVˆê˜YA‰i’ÃrŽ¡AΕŒ[Ži@ƒnƒ“ƒ`ƒ“ƒgƒ“•aƒmƒbƒNƒCƒ“ƒ}ƒEƒX‚É‚¨‚¯‚éƒ|ƒŠƒOƒ‹ƒ^ƒ~ƒ“‹ÃW‘ÌŒ`¬‚ÉŠÖ‚·‚錤‹†@‘æ25‰ñ“ú–{_Œo‰ÈŠw‘å‰ï@“Œ‹ž (2002)

‰Hª“cç]”üA…–ì‘P•¶A‚‹´‹v‰p@Ž©‘R”­Çƒnƒ€ƒXƒ^[(UM-X7.1)‚ÌœŒ`¬ˆÙí@‘æ36‰ñ“ú–{ŽÀŒ±“®•¨‹ZpŽÒ‹¦‰ï‘‰ï@–kŠC“¹@(2002)

’·”öÃŽqACowley, BD Jr. ‘½”­«”X–EtÇ‚Æ‘–‰»ˆöŽq@‘æ44‰ñ“ú–{t‘ŸŠw‰ï@“Œ‹ž@(2001)

’·”öÃŽqACowley, BD Jr. ƒ‰ƒbƒg‘½”­«”X–EtǂƉŠÇ«‘–‰»ˆöŽq‚Ì‘‰Á‚ɂ‚¢‚Ä@‘æ48‰ñ“ú–{ŽÀŒ±“®•¨Šw‰ï@“Œ‹ž@(2001)



ŒfÚ‚Ì•¶ÍEŽÊ^E}•\‚È‚Ç‚Ì–³’f“]Ú‚ð‹ÖŽ~‚µ‚Ü‚·B’˜ìŒ ‚ÍŽ¾Š³ƒ‚ƒfƒ‹‹³ˆçŒ¤‹†ƒZƒ“ƒ^[‚É‘®‚µ‚Ü‚·B